Journal of Diabetes Research

Research Article

Comparative Assessment of the Long-Term Effectiveness and Safety of Dapagliflozin and Empagliflozin as Add-on Therapy to Hypoglycemic Drugs in Patients with Type 2 Diabetes

Table 2

Changes in clinical parameters from baseline with dapagliflozin or empagliflozin.


	Dapagliflozin ()			Empagliflozin ()			value‡
	Baseline	36 months	value†	Baseline	36 months	value†	value‡

HbA1c, %	8.0 (7.6, 8.6)	7.0 (6.6, 7.7)	<0.001	7.9 (7.4, 9.3)	7.2 (6.8, 7.9)	<0.001	0.324
Body weight, kg	75 (66, 84)	73 (66, 80)	<0.001	74 (64, 84)	71 (62, 80)	<0.001	0.798
SBP, mmHg	142 (131, 155)	131 (120, 140)	<0.001	144 (129,150)	132 (120, 140)	<0.001	0.379
DBP, mmHg	80 (74, 89)	80 (72, 87)	0.228	81 (73, 87)	77 (68, 82)	<0.001	0.081
FPG, mg/dL	161 (137, 186)	136 (117, 156)	<0.001	167 (134, 188)	126 (113, 156)	<0.001	0.171
ALT, IU/L	30 (23, 43)	24 (19, 37)	<0.001	26 (20, 36)	23 (19, 30)	0.005	0.158
Scr, mg/dL	0.79 (0.60, 0.95)	0.79 (0.61, 0.99)	0.228	0.90 (0.74, 1.02)	0.90 (0.75, 1.07)	0.174	0.998
eGFR, mL/min/1.73 m²	89 (74, 105)	86 (74, 107)	0.898	78 (69, 97)	82 (70, 95)	0.723	0.933
CHOL(T), mg/dL	150 (128, 173)	152 (136, 165)	0.913	161 (138, 183)	153 (131, 179)	0.064	0.150
Triglyceride, mg/dL	127 (97, 177)	110 (76, 162)	0.031	115 (96, 174)	107 (74, 160)	0.037	0.907
LDL-C, mg/dL	82 (66, 96)	80 (71, 98)	0.846	90 (72, 111)	83 (62, 97)	0.019	0.059
HDL-C, mg/dL	43 (37, 49)	42 (37, 53)	0.275	40 (34, 50)	43 (37, 52)	0.194	0.718

Data are shown as median (IQR). ALT: alanine aminotransferase; CHOT(T): total cholesterol; DBP: diastolic blood pressure; eGFR: estimated glomerular filtration rate; FPG: fasting plasma glucose; HbA1c: hemoglobin A1c; HDL-C: high-density lipoprotein-cholesterol level; LDL-C: low density lipoprotein-cholesterol level; SBP: systolic blood pressure; Scr: serum creatinine. †Wilcoxon sign rank test was used to compare of differences within groups measured at baseline and 36 months. ‡Mann–Whitney test was used to compare of differences between groups measured at baseline and 36 months. value <0.05 were considered statistically significant.