Autoantibodies to Zinc Transporter 8 and SLC30A8 Genotype in Type 1 Diabetes Childhood: A Pioneering Study in North Africa

Table 3

Gender and prevalence of specific autoantibodies in ZnT8A positive (ZnT8-Ab+) and ZNT8-Ab negative (ZnT8-Ab-) in 156 type 1 diabetic (T1D) newly diagnosed children, based on the age at diagnosis (AAD).

									value
	ZnT8-Ab+	ZnT8-Ab-	ZnT8-Ab+	ZnT8-Ab-	ZnT8-Ab+	ZnT8-Ab-	ZnT8-Ab+	ZnT8-Ab-	ZnT8-Ab+
(%)	25 (16.02)	31 (19.87)	30 (19.23)	20 (12.82)	55 (35.25)	51 (32.69)	32 (20.51)	18 (11.53)	0.037
Sex ratio (F/M)	1	1.18	1.09	1.4	1.04	1.2	0.56	0.42	—
ZnT8-Ab titer (UI/ml)								0	0.009
GADA titer (UI/ml)									NS
IA-2A titer (UI/ml)									NS

T1D: type 1 diabetes; ZnT8-Ab: zinc transporter 8 autoantibodies; GADA: glutamic acid decarboxylase autoantibodies; IA-2A: antiprotein tyrosine phosphatase- (PTP-) like antigen IA-2 autoantibodies.