Journal of Diabetes Research

Research Article

Autoantibodies to Zinc Transporter 8 and SLC30A8 Genotype in Type 1 Diabetes Childhood: A Pioneering Study in North Africa

Table 4

Six clinical, immunological, and genetic T1D variables were included in PC analysis. The factor-loading matrix for two principal components illustrates the stronger or weaker influence of each variable on each component. Variables displaying an absolute factor (in italic) were considered representative of each PC. A positive sign in the factor indicates that the PC was influenced by higher values of the original variable, while a negative sign indicates the influence of lower values.


Variable selected for PC analysis	Attribute name^a	Extracted components
Variable selected for PC analysis	Attribute name^a	PC-1	PC-2

GADA titers	GAD	-0.038	0.582
IA-2A titers	IA2A	0.158	-0.258
ZnT8-Ab titers	ZnT8	0.794	-0.067
rs13266634 genotype	C/T	0.130	-0.719
Age at diagnosis	AAD	0.691	0.497
Gender	SEX	-0.509	0.263

^aThe attribute name is the same reported in Figure 2. ZnT8-Ab: zinc transporter 8 antibodies; GADA: glutamic acid decarboxylase antibodies; IA-2A: antiprotein tyrosine phosphatase- (PTP-) like antigen IA-2 antibodies.