Review Article

Evidence and Potential Mechanisms of Traditional Chinese Medicine for the Adjuvant Treatment of Coronary Heart Disease in Patients with Diabetes Mellitus: A Systematic Review and Meta-Analysis with Trial Sequential Analysis

Table 1

Summary of included studies.

StudyPatient groupParticipant (M/W)Treatment measureDurationOutcomes
ControlTreatmentControlTreatment

Chen 2019T2DM&CHD 12864 (29/35)64 (31/33)CTYanshi Yixin decoction+CT3 mBG, BL, SAA, MMP-9, TBIL
Cheng 2019T2DM&CHD 1186058CTSupplemented Yuye decoction+CT3 mBG, BL, IM, SOD, MDA, GSH-Px, 8-ios-PGF2a
Feng 2020T2DM&CHD 13065 (33/32)65 (35/30)CTShexiang Baoxin Pill+CT3 mBL
Gao 2018T2DM&CHD 10050 (27/23)50 (24/26)CTShengmai powder+CT2 mBG, BL, FGF-21, Ghrelin
Li 2008DM&CHD 10050 (33/17)50 (32/18)CTJiangtang Shengmai decoction+CT2 mBG, BL, HI
Li 2021T2DM&CHD 286143 (75/68)143 (76/67)CTTongxinluo capsule+CT3 mCF, BL, BG
Liu 2008T2DM&CHD 260130 (95/35)130 (89/41)CTXinshu pill+CT2 mBG, IM, DD, LFTs, KFTs
Liu 2019T2DM&CHD 10854 (29/25)54 (28/26)CTShexiang Yangxin powder+CT3 mBG, BL, HI
Ni 2010T2DM&CHD 17345 (21/24)128 (55/73)CTQizhi Jiangtang capsule+CT2 mBG, dynamic ECG
Ning 2017T2DM&CHD 15075 (34/41)75 (35/40)CTYindan Xinnaotong soft capsule+CT3 mHI, angina frequency
Pan 2019T2DM&SAP 12060 (29/31)60 (28/32)CTYiqi Yangyin Huoxue decoction_CT3 mBG, BL, CRP, Hcy, UMA
Qian 2017DM&ACS 294147 (97/50)147 (102/45)CTXinyue capsule+CT6 mCE, BG, NT-proBNP, CK-MB
Qian 2018T2DM&CHD 15075 (43/32)75 (45/30)CTTongguan Huoxue decoction+Naoxintong capsule+CT3 mBG, BL, HMGB1, Omentin-1
Ren 2020T2DM&CHD 320160 (85/75)160 (78/82)CTTongguan Huoxue decoction+Naoxintong capsule+CT3 mCF, BG
Shi 2020T2DM&CHD 12060 (16/44)60 (18/42)CTYindan Xinnaotong soft capsule+CT3 mAngina frequency, BL
Tao 2017T2DM&CHD 11855 (33/22)63 (43/20)CTHedan pill+CT6 mBL, IM, SOD, MDA, NO
Zhang 2015T2DM&CHD 10251 (30/21)51 (28/23)CTShuxin Huoxue decoction+CT2 mBL, IM, HI
Zhang 2019T2DM&SAP 17981 (43/38)98 (49/49)CTYiqi Yangyin decoction+CT3 mCE, BG, BL, HI, IM
Zhang 2020DM&CHD 13467 (36/31)67 (34/33)CTXuezhikang+CTBG, BL, HI, IM, CF
Zhao 2007T2DM&CHD 591285 (198/87)306 (226/80)Placebo+CTXuezhikang+CT4 yACM, CE, BL

ACS: acute coronary syndrome; SAP: stable angina pectoris; CT: conventional treatment; ACM: all-cause mortality; CE: cardiovascular events; CF: cardiac function; HI: hemorrheologic indices; IM: inflammatory marks; BG: blood glucose; BL: blood lipid.