Journal of Diabetes Research

Research Article

Serum Antithyroglobulin Antibody Levels Are Associated with Diabetic Retinopathy among Euthyroid Type 2 Diabetes Patients: A Hospital-Based, Retrospective Study

Table 3

Associations between thyroid indicators and various stages of DR risk.


		Overall DR	Mild NPDR	Moderate NPDR	Severe NPDR or PDR

TSH	T1 (ref)	1	1	1	1
	T2 (model 1)	1.000 (0.745, 1.343)	0.924 (0.672, 1.271)	1.322 (0.633, 2.761)	1.111 (0.588, 2.102)
	T2 (model 2)	0.990 (0.734, 1.333)	0.917 (0.665, 1.264)	1.274 (0.607, 2.674)	1.133 (0.596, 2.152)
	T3 (model 1)	1.110 (0.828, 1.489)	1.139 (0.834, 1.556)	1.083 (0.502, 2.335)	0.892 (0.456, 1.744)
	T3 (model 2)	1.062 (0.789, 1.431)	1.116 (0.814, 1.529)	0.954 (0.437, 2.081)	0.851 (0.431, 1.680)
	Per SD increase (model 1)	1.055 (0.938, 1.187)	1.081 (0.954, 1.225)	1.049 (0.783, 1.404)	0.893 (0.679, 1.174)
	Per SD increase (model 2)	1.043 (0.926, 1.175)	1.072 (0.945, 1.216)	1.017 (0.757, 1.367)	0.891 (0.675, 1.176)

FT4	T1 (ref)	1	1	1	1
	T2 (model 1)	0.992 (0.740, 1.330)	0.993 (0.724, 1.361)	0.930 (0.453, 1.909)	1.050 (0.551, 2.000)
	T2 (model 2)	1.035 (0.768, 1.395)	1.030 (0.748, 1.418)	0.973 (0.471, 2.010)	1.073 (0.562, 2.050)
	T3 (model 1)	1.013 (0.755, 1.358)	1.064 (0.777, 1.458)	0.813 (0.385, 1.713)	0.953 (0.492, 1.845)
	T3 (model 2)	0.983 (0.728, 1.328)	1.069 (0.776, 1.471)	0.808 (0.379, 1.726)	0.826 (0.421, 1.620)
	Per SD increase (model 1)	1.035 (0.967, 1.109)	1.047 (0.973, 1.127)	0.985 (0.827, 1.172)	0.983 (0.843, 1.147)
	Per SD increase (model 2)	1.028 (0.959, 1.102)	1.042 (0.968, 1.122)	0.984 (0.826, 1.173)	0.968 (0.831, 1.128)
FT3	T1 (ref)	1	1	1	1
	T2 (model 1)	1.302 (0.972, 1.745)	1.394 (1.017, 1.912)^c	1.243 (0.622, 2.483)	0.739 (0.386, 1.416)
	T2 (model 2)	1.349 (0.997, 1.824)	1.426 (1.031, 1.971)^c	1.146 (0.566, 2.320)	0.840 (0.431, 1.637)
	T3 (model 1)	1.011 (0.750, 1.363)	1.148 (0.831, 1.586)	0.652 (0.289, 1.471)	0.802 (0.423, 1.521)
	T3 (model 2)	1.031 (0.757, 1.405)	1.179 (0.844, 1.647)	0.588 (0.254, 1.363)	0.846 (0.434, 1.646)
	Per SD increase (model 1)	1.016 (0.837, 1.235)	1.051 (0.853, 1.295)	0.876 (0.538, 1.425)	0.973 (0.632, 1.499)
	Per SD increase (model 2)	1.016 (0.829, 1.246)	1.061 (0.853, 1.318)	0.744 (0.445, 1.244)	1.047 (0.673, 1.628)

TPOAb	Negative	1	1	1	1
	Positive (model 1)	1.069 (0.753, 1.517)	1.180 (0.816, 1.706)	0.826 (0.320, 2.128)	0.753 (0.318, 1.786)
	Positive (model 2)	1.085 (0.761, 1.547)	1.191 (0.822, 1.726)	0.859 (0.332, 2.226)	0.749 (0.314, 1.785)

TgAb	Negative	1	1	1	1
	Positive (model 1)	1.108 (0.818, 1.502)	0.852 (0.609, 1.192)	1.270 (0.618, 2.613)	2.247 (1.269, 3.981)^c
	Positive (model 2)	1.112 (0.818, 1.511)	0.849 (0.606, 1.190)	1.343 (0.649, 2.780)	2.212 (1.244, 3.934)^c

Model 1: crude; Model 2: adjusted for age, sex, BMI, SBP, and HbA_1c. The superscript c indicates that the value of corresponding OR is less than 0.05.