Vitamin D Supplementation for the Treatment of Depressive Symptoms in Women with Type 2 Diabetes: A Randomized Clinical Trial

Table 1

Baseline Characteristics by Treatment Allocation.

Baseline Characteristics	Lower Dose; (n = 64)	Higher Dose; (n = 65)	Total; (N = 129)
Mean age (SD)	51.14 (9.40)	50.02 (12.65)	50.58 (11.13)
Median years with diabetes (IQR)	8 (4-13)	8 (4-12)	8 (4-12)
Race (N = 128)
White	34 (54%)	29 (45%)	63 (49%)
Black	28 (44%)	34 (52%)	62 (48%)
Asian or Pacific Islander	1 (1.6%)	1 (1.5%)	2 (1.6%)
Arabic	0	1 (1.5%)	1 (0.8%)
Hispanic Ethnicity	11 (17%)	12 (18%)	23 (18%)
Use of anti-depressants (N = 128)	11 (17%)	12 (19%)	23 (18%)
Season of First Dose (N = 128)
Fall	12 (19%)	15 (23%)	27 (21%)
Winter	22 (34%)	22 (34%)	44 (34%)
Spring	16 (25%)	17 (27%)	33 (26%)
Summer	14 (22%)	10 (16%)	24 (19%)
Screening Mood Measures
Mean CES-D (SD)	28.41 (8.39)	28.72 (8.50)	28.57 (8.41)
Mean PHQ-9 (SD)	11.91 (4.20)	11.74 (4.29)	11.82 (4.23)
Vitamin D Laboratory Values (ng/mL)
Median 25 (OH) D2 (IQR)	4 (4-4)	4 (4-4)	4 (4-4)
Mean 25 (OH) D3 (SD)	18.61 (6.66)	20.63 (6.60)	19.63 (6.68)
Mean Total 25 (OH) D (SD)	20.19 (6.40)	21.49 (6.52)	20.84 (6.47)
Physical and Other Laboratory Measures
Median PTH (IQR) (pg/mL)	49 (36-69)	49 (38-59)	49 (36-64)
Median calcium (IQR) (mg/dL)	9.4 (9.2 – 9.7)	9.4 (9.2-9.6)	9.4 (9.2-9.6)
Creatinine (SD) (mg/dL)	0.74 (0.14)	0.75 (0.15)	0.75 (0.14)
Mean systolic blood pressure (SD) (mmHg)	128.41 (16.40)	127.43 (14.96)	127.91 (15.63)
Mean diastolic blood pressure (SD) (mmHg)	71.97 (10.64)	70.94 (8.75)	71.45 (9.71)
Mean body mass index (SD)	39.10 (8.28)	37.65 (7.71)	38.37 (8.00)
Mean HbA1c (SD) (%)	7.86 (1.97)	7.68 (1.69)	7.77 (1.83)
Mean fasting glucose (SD) (mg/dL)	170.47 (68.63)	152.52 (48.76)	161.43 (59.90)

Note. Valid N = 129 unless otherwise indicated. SD = Standard deviation of the mean. IQR = Interquartile range.