Vitamin D Supplementation for the Treatment of Depressive Symptoms in Women with Type 2 Diabetes: A Randomized Clinical Trial

Table 2

Summary of Relevant Adverse Events.

Adverse Event	Higher Dose (n = 65)		Lower Dose (n = 64)
	Number Affected	Number of Events	Number Affected	Number of Events
Passive suicidal ideation	3 (4.6%)	3	1 (1.6%)	1
Significant increase in CES-D (30% increase)	14 (22%)	14	15 (23%)	15
Elevated vitamin D level (≥ 100 ng/mL)	2 (3.1%)	2	0	0
Hypercalcemia (> 10.5 mg/dL)	1 (1.5%)	1	1 (1.6%)	1
Elevated systolic blood pressure (≥ 160mmHg)	6 (9.2%)	8	6 (9.4%)	7
Significant increase in HbA1c (3%)	1 (1.5%)	1	4 (6.3%)	4
Significant increase in creatinine (25%)	1 (1.5%)	1	0	0

Note. The number affected may not equal the number of events, principally because an individual can report the same event multiple times.