Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese Population
Table 2
Factors associated with the presence of nonobese NAFLD in the HOMA-IR >1 group.
Model 1
Model 2
Model 3
Model variables
OR (95% CI)
value
OR (95% CI)
value
OR (95% CI)
value
Gender
Female
1.00
—
—
—
—
Male
1.261 (0.801-1.987)
0.317
—
—
—
—
Age (years)
18-30
1.00
1.00
1.00
31-40
1.064 (0.567-1.994)
0.847
1.064 (0.567-1.994)
0.847
1.118 (0.425-2.938)
0.821
41-50
1.715 (0.903-3.256)
0.099
1.715 (0.903-3.256)
0.099
2.492 (0.919-6.759)
0.073
>50
2.082 (1.105-3.923)
0.023
2.082 (1.105-3.923)
0.023
3.253 (1.224-8.647)
0.018
Body mass index (kg/m2)
18.5-22.9
1.00
1.00
1.00
23.0-24.9
6.687 (4.198-10.653)
<0.001
6.687 (4.198-10.653)
<0.001
5.532 (2.830-10.813)
<0.001
Alanine aminotransferase (U/L)
≤17
1.00
—
—
>17
4.143 (2.616-6.561)
<0.001
4.525 (2.811-7.285)
<0.001
—
—
Aspartate aminotransferase (U/L)
≤18
1.00
1.00
1.00
>18
2.248 (2.085-5.060)
<0.001
3.458 (2.194-5.451)
<0.001
2.326 (1.192-4.539)
0.013
Total cholesterol (mmol/L)
≤4.71
1.00
—
—
—
—
>4.71
1.266 (0.831-1.926)
0.272
—
—
—
—
High-density lipoprotein cholesterol (mmol/L)
≥1.36
1.00
1.00
—
—
<1.36
1.982 (1.293-3.036)
0.002
1.982 (1.293-3.036)
0.002
—
—
Triglyceride (mmol/L)
≤0.9
1.00
1.00
1.00
>0.9
5.805 (3.582-9.408)
<0.001
6.017 (3.677-9.846)
<0.001
6.069 (2.899-12.708)
<0.001
Low-density lipoprotein cholesterol (mmol/L)
≤2.65
1.00
1.00
—
—
>2.65
1.620 (1.062-2.470)
0.025
1.636 (1.066-2.510)
0.024
—
—
Glucose (mmol/L)
≤5.25
1.00
1.00
1.00
>5.25
6.860 (4.288-10.976)
<0.001
7.400 (4.555-12.022)
<0.001
2.953 (1.376-6.339)
<0.001
Homeostasis model assessment-beta (%)
≤5.5
1.00
1.00
1.00
>5.5
6.985 (4.374-11.156)
<0.001
6.985 (4.374-11.156)
<0.001
5.434 (2.765-10.682)
<0.001
Fasting insulin (uIU/mL)
≤3.89
1.00
1.00
1.00
>3.89
5.127 (3.262-8.059)
<0.001
5.280 (3.328-8.378)
<0.001
2.890 (1.492-5.598)
0.002
Homeostasis model assessment-beta (%)
≥47.1
1.00
1.00
1.00
<47.1
9.870 (5.532-17.612)
<0.001
12.194 (6.643-22.381)
<0.001
7.460 (3.051-18.238)
<0.001
Abbreviations: 95% CI: 95% confidence interval; OR: odds ratio; †: the presence or absence of NAFLD was the dependent variable. Model 1: not adjusted for any confounding factors. Model 2: adjusted for gender and age. Model 3: adjusted for variables included in the model such as gender; age (years) 31 to 40, 41 to 50, and >50; BMI (kg/m2) 23.0 to 24.9; U/L; U/L; mmol/L; mmol/L; mmol/L; mmol/L; mmol/L; %; and %.
