Longitudinal Associations of Newly Diagnosed Prediabetes and Diabetes with Cognitive Function among Chinese Adults Aged 45 Years and Older

Table 2

Eight-year association between baseline diabetic status and subsequent cognitive function (multivariable analyses).

Baseline diabetic status	Cognitive function (follow-up, )
	Model 1		Model 2		Model 3
	Unstandardized estimate (95% CI)	value	Unstandardized estimate (95% CI)	value	Unstandardized estimate (95% CI)	value
Others^a	Ref.		Ref.		Ref.
Prediabetes	-0.006 (-0.29~0.28)	0.965	0.009 (-0.26~0.27)	0.944	0.03 (-0.28~0.35)	0.839
Diabetes	-0.57 (-0.96~-0.18)	0.004	-0.31 (-0.67~0.04)	0.083	-0.50 (-0.98~-0.02)	0.041

Abbreviation: 95% CI: 95% confidence interval; Ref: reference. ^aOthers, individuals without prediabetes or diabetes. Model 1: adjusting for age, gender, marital status, education level, ever smoking, ever drinking, self-comment about health, hypertension, dyslipidemia, BMI, and depressive symptoms at baseline. Model 2: adjusting for the variables in model 1 plus cognitive function at baseline. Model 3: adjusting for the variables in model 2 plus clinical variables including blood urea nitrogen, creatinine, triglycerides, HDL cholesterol, LDL cholesterol, high-sensitivity C-reactive protein, hemoglobin, cystatin C, and HbA_1c.