Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome

Table 2

Allele and genotype frequency distribution of LEP (rs7799039) and ADIPOQ (rs2241766) gene polymorphisms in patients with MS.

LEP (rs7799039) gene
Groups	MS patients, (%)	Control group, (%)
Alleles
G	215 (51.9)	114.0 (57.0)	0.57
А	199 (48.1)	86.0 (43.0)	0.57
Allele combinations
GG	55 (26.6)	31 (31.0)	0.64
GA	105(50.7)	52 (52.0)	1.0
AA	47 (22.7)	17 (17.0)	0.38
ADIPOQ (rs2241766) gene
Alleles	MS patients	Control group		OR (95% СI)
	MS patients, (%)	Control group, (%)
Alleles
T	277 (66.9)	185 (92.5)	<0.001	0.17 (0.07-0.41)
G	137 (33.1)	15 (7.5)	<0.001	5.6 (2.4-13.0)
Allele combinations
TT	105 (50.7)	87 (87.0)	<0.001	0.1 (0.07-0.31)
TG	67 (32.4)	11 (11.0)	<0.001	3.81 (1.79-8.09)
GG	35 (16.9)	2 (2.0)	<0.001	10.0 (2.25-44.7)

: number of subjects; ns: not significant; OR: odds ratio.