In Vitro and In Vivo Improvement of Islet Quality and Transplantation Successes following Islet Treatment with Biomaterials in Diabetic Rats

Table 2

The effect of PRP and PIH on animal weight, serum glucose, and insulin concentration.

Parameter/group	Con	D	IT	IT-PRP	IT- PIH	IT- PRP&PIH
Average initial weight (g)
Average final weight (g)	g4	a4g2	a2g3	a1b2c1g4	a2g3	b3c2e1g4
Percentage of weight gain (%)		a4	a3b3	a2b4c2e1	a3b3	a1b4c3d2e3
Average glucose day 0 (mg/dl)		a4	a4	a4	a4	a4
Average glucose day 60 (mg/dl)		a4g1	a3b2g1	b4c2e1g4	a2b2c1g3	b4c3d2e2g4
Average insulin day 0 (ng/ml)	0.8	0.23; a4	0.22; a4	0.23; a4	0.22; a4	0.23; a4
Average insulin day 60 (ng/ml)	0.84	0.24; a4	0.38; a3g1	0.59; a2b2c1g3	0.47; a2b1g2	0.74; b4c3d1e2g4

Data are presented as (). ^aStatistically significant differences compared to control. ^bStatistically significant differences compared to the D group. ^cStatistically significant differences compared to the IT group. ^dStatistically significant differences compared to the IT-PRP group. ^eStatistically significant differences compared to the IT-PIH group. ^gStatistically significant differences compared to day 0 in the same group. ¹, ², ³, and ⁴. Con: control rats; D: control diabetic rats; IT: islet-transplanted diabetic rats; IT-PRP: islet-transplanted diabetic rats with PRP; IT-PIH: islet-transplanted diabetic rats with PIH; IT-PRP&PIH: islet-transplanted diabetic rats with PRP&PIH.