The Health-Promoting Effects and the Mechanism of Intermittent Fasting

Table 4

Information about IF and cancer.

Information	Method	Sample feature	Results	Discussion
Cooper [45]	Nonrandomized controlled experiments on animals	Male Fox Chase SCID mice injected in the flank with LAPC-4 cells were randomized to seven groups	IGF-1↓; survival percentage↑ (after 20 days)	Tumor growth was not significantly inhibited, but the survival rate was improved.
Stefanie [46]	Randomized controlled experiments in humans	HER2-negative II/III breast cancer patients	Toxicity grade III/IV of the subjects (NA); DNA damage in T lymphocytes↓	FMD has significant benefits in increasing the sensitivity of breast cancer cells to chemotherapy.
Cui [47]	Nonrandomized controlled experiments on animals	IF group (); AL group ()	TFR, TV, damage to the liver caused by liver cancer↓	IF can reduce tumorigenesis, inhibit tumorigenesis, reduce the degree of liver injury during tumorigenesis, and maintain normal lipid metabolism.

Note: SCID: severe combined immunodeficiency; LAPC-4: Los Angeles prostate cancer-4; NA: not analyzed; TFR: tumor formation rate; TV: tumor volume; Glu: blood glucose.