The Health-Promoting Effects and the Mechanism of Intermittent Fasting

Table 6

Information about IF and senescence.

Information	Method	Sample feature	Results	Discussion
Humaira [73]	Nonrandomized controlled experiments in humans	Overweight adults	Glu↓; ketones, cholesterol, BDNF, SIRT1, LC3A↑	TRF improves cardiac metabolic health, alters circadian rhythms, and has antiaging effects.
Rong [74]	Nonrandomized controlled experiments on animals	Male elderly Wistar rat tumorigenesis	BW, HDL-C, LDL-C↓↓; GT↓; FPG↑↑	IF can improve the intestinal flora and reduce the body mass and blood lipid levels of obese rats in the presenile period.
Hu [75]	Nonrandomized controlled experiments on animals	ApoE mice with atherosclerosis (); AS mouse IF group (); AL group ()	MMP-9, CC, FC, LC↓	IF reduced the area of atherosclerotic plaque and delayed the progression of atherosclerosis in AS mice.

Note: BW: body weight; HDL-C; LDL-C; Glu: blood glucose; FPG: fasting glucose; GT: glucose tolerance; CC: cholesterol crystals; FC foam cells; CF fibrous cap; LC lipid core; LC3A: microtubule-associated protein 1A/1B-light chain 3A.