The Health-Promoting Effects and the Mechanism of Intermittent Fasting

Table 7

Information about IF and metabolism.

Information	Method	Sample feature	Results	Discussion
Deng [15]	Nonrandomized controlled experiments on animals	Obesity model mice	LPS, TNF-α, IL-1β↓↓	The short-term improvement effect of IF is limited, while the long-term intermittent fasting can significantly improve the inflammatory state.
Froy [82]	Randomized controlled experiments on animals	FVB/N wild-type (W) mice and FVB/N mice-derived transgenic MUPA mice	mPer2, mCry1, mClock, mBmal1↓	IF can affect circadian rhythms depending on the timing of food availability and induces a metabolic state that affects the suprachiasmatic nucleus (SCN) clock.

Note: the FVB/NJ mouse strain has its origins in a colony of outbred Swiss mice established in 1935 at the National Institutes of Health. FVB/NJ mice; LPS: lipopolysaccharide; Mper2: mammalian period; Mcry1: mammalian cryptochrome 1; Mclock: mammalian clock proteins; Mbmal1: mammalian brain–muscle-Arnt-like 1.