Research Article
Precedence of Bone Loss Accompanied with Changes in Body Composition and Body Fat Distribution in Patients with Type 2 Diabetes Mellitus
Table 1
Demographic data of 596 patients with T2DM.
| | Total | Decreased BMI group | Stable BMI group | Increased BMI group | | Baseline | Endpoint | | Baseline | Endpoint | | Baseline | Endpoint | | Baseline | Endpoint | |
| | 596 | 596 | / | 221 | 221 | / | 188 | 188 | / | 187 | 187 | / | | Age (yr) | 61 (53-68) | 64 (56-70) | <0.001 | 62 (53-69) | 64 (55-71) | <0.001 | 63 (54-70) | 65 (56-72) | <0.001 | 61 (53-68) | 63 (54-70) | <0.001 | | Male, (%) | 308 (51.68) | / | / | 114 (51.6) | / | / | 104 (55.3) | / | / | 90 (48.1) | / | / | | T2DM course (yr) | 8.00 (3.00-13.00) | 10.58 (5.33-14.75) | <0.001 | 8.00 (3.00-13.50) | 10.08 (5.08-15.71) | <0.001 | 8.50 (3.00-13.00) | 10.58 (5.27-14.67) | <0.001 | 9.00 (4.00-12.00) | 10.92 (5.83-14.42) | <0.001 | | DR, (%) | 106 (17.79) | 160 (26.85) | <0.001 | 28 (12.67) | 42 (19.00) | <0.001 | 31 (16.49) | 56 (29.79) | <0.001 | 47 (25.13) | 62 (33.16) | <0.001 | | DPN, (%) | 262 (43.96) | 322 (54.03) | <0.001 | 83 (37.56) | 115 (52.04) | <0.001 | 90 (47.87) | 100 (53.19) | <0.001 | 89 (47.59) | 107 (57.22) | <0.001 | | DKD, (%) | 107 (17.95) | 164 (27.52) | <0.001 | 37 (16.74) | 56 (25.34) | <0.001 | 34 (18.09) | 51 (27.13) | <0.001 | 36 (19.25) | 57 (30.48) | <0.001 | | HT, (%) | 313 (52.52) | / | / | 120 (54.3) | / | / | 100 (53.2) | / | / | 93 (49.7) | / | / | | Smoking, (%) | 96 (16.11) | / | / | 36 (16.3) | / | / | 36 (19.1) | / | / | 24 (12.8) | / | / | | Drinking, (%) | 147 (24.66) | / | / | 10 (4.5) | / | / | 8 (4.3) | / | / | 129 (68.6) | / | / | | SBP (mmHg) | 136 (122-150) | 135 (125-149) | 0.264 | 137 (123-150) | 133 (121-149) | 0.150 | 136 (120-148) | 134 (124-148) | 0.353 | 135 (124-149) | 139 (128-153) | 0.005 | | DBP (mmHg) | 78 (70-84) | 78 (71-85) | 0.762 | 79 (70-84) | 78 (70-85) | 0.402 | | | 0.071 | | | 0.178 | | FPG (mmol/l) | 7.72 (5.87-11.11) | 7.08 (5.25-9.84) | <0.001 | 7.62 (5.84-10.68) | 6.80 (5.38-9.49) | 0.003 | 7.72 (5.90-11.47) | 7.24 (5.11-10.29) | 0.018 | 8.21 (5.91-11.15) | 7.22 (5.30-11.50) | 0.001 | | HbA1c (%) | 8.66 (7.10-10.81) | 7.90 (6.70-9.70) | <0.001 | 8.40 (7.00-10.20) | 7.60 (6.50-9.75) | 0.007 | 8.30 (7.10-10.81) | 7.90 (6.80-9.80) | 0.001 | 9.40 (7.60-11.50) | 8.00 (6.70-9.30) | <0.001 | | TC (mmol/l) | 4.60 (3.85-5.38) | 4.29 (3.54-5.08) | <0.001 | | | <0.001 | 4.62 (3.76-5.30) | 4.34 (3.57-5.12) | 0.025 | 4.66 (3.96-5.42) | | 0.001 | | TG (mmol/l) | 1.44 (0.95-2.16) | 1.35 (0.98-2.05) | 0.481 | 1.45 (0.98-2.18) | 1.27 (0.92-1.93) | 0.007 | 1.41 (0.93-2.12) | 1.39 (1.00-2.14) | 0.732 | 1.42 (0.94-2.16) | 1.47 (1.00-2.28) | 0.216 | | HDL-C (mmol/l) | 1.12 (0.92-1.34) | 1.03 (0.87-1.27) | <0.001 | 1.10 (0.94-1.30) | 1.03 (0.89-1.24) | 0.003 | 1.16 (0.94-1.34) | 1.01 (0.87-1.25) | <0.001 | | | 0.002 | | LDL-C (mmol/l) | 2.83 (2.14-3.45) | 2.64 (1.94-3.31) | 0.001 | | | 0.005 | | | 0.973 | 2.85 (2.26-3.53) | 2.67 (2.01-3.36) | 0.004 | | Metformin, (%) | 370 (62.08) | 423 (70.97) | <0.001 | 147 (66.52) | 167 (75.57) | <0.001 | 114 (60.64) | 126 (67.02) | <0.001 | 109 (58.29) | 129 (69.52) | <0.001 | | Insulin, (%) | 215 (36.07) | 315 (52.85) | <0.001 | 71 (32.13) | 95 (42.99) | <0.001 | 66 (35.11) | 107 (56.91) | <0.001 | 78 (41.71) | 113 (60.43) | <0.001 | | L1-4BMD (g/cm2) | 1.06 (0.92-1.17) | 1.05 (0.93-1.18) | 0.223 | 1.06 (0.93-1.16) | 1.06 (0.93-1.16) | 0.190 | 1.05 (0.90-1.18) | 1.04 (0.92-1.20) | 0.060 | 1.05 (0.93-1.16) | 1.06 (0.94-1.18) | 0.031 | | FNBMD (g/cm2) | 0.92 (0.80-1.03) | 0.86 (0.75-0.96) | <0.001 | 0.93 (0.79-1.09) | 0.86 (0.74-0.98) | <0.001 | 0.91 (0.80-0.99) | 0.84 (0.77-0.93) | <0.001 | 0.91 (0.83-1.00) | 0.87 (0.77-0.97) | <0.001 |
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Note: BMI: body mass index; T2DM: type 2 diabetes mellitus; DR: diabetic retinopathy; DPN: diabetic peripheral neuritis; DKD: diabetic kidney disease; HT: hypertension; SBP: systolic blood pressure; DBP: diastolic blood pressure; FPG: fasting plasma glucose; HbA1c: glycated hemoglobin; TC: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol. . |
