Clinical Characteristics Associated with Adherence and Persistence in Patients with Type 2 Diabetes Mellitus Treated with Dulaglutide
Table 3
Factors affecting PDC and treatment duration.
PDC
Treatment duration
Factor
β-Coefficient (95% CI)
value
Factor
β-Coefficient (95% CI)
value
All patients ()
Age
0.006 (0.002, 0.010)
0.002
Age
2.17 (0.78, 3.55)
0.002
eGFR
0.002 (-0.0003, 0.0003)
0.11
eGFR
0.55 (-0.12, 1.23)
0.11
Switching dose
0.09 (0.003, 0.18)
0.04
Switching dose
32.9 (0.81, 64.9)
0.04
Baseline insulin
-0.11 (-0.21, -0.005)
0.04
Baseline insulin
-38.9 (-76.1, -1.68)
0.04
Baseline sulfonylurea
-0.13 (-0.23, -0.022)
0.02
Baseline sulfonylurea
-43.6 (-83.2, -8.08)
0.02
Baseline obesity
-0.12 (-0.27, 0.03)
0.12
Baseline obesity
-43.4 (-98.3, 11.5)
0.12
Baseline neuropathy
0.14 (0.01, 0.27)
0.04
Baseline neuropathy
50.6 (2.94, 98.3)
0.04
Baseline CVD
-0.11 (-0.24, 0.03)
0.12
Baseline CVD
-39.2 (-88.4, 10.0)
0.12
Patients with ≥2 identifiable CVD risk(s) ()
Age
0.006 (0.001, 0.011)
0.009
Age
2.23 (0.54, 3.91)
0.001
Male sex
0.079 (-0.023, 0.180)
0.129
Male sex
28.48 (-8.69, 65.66)
0.132
TG
0.0004 (-0.00008, 0.0009)
0.103
TG
0.147 (-0.03, 0.323)
0.103
eGFR
0.0028 (0.0006, 0.0049)
0.015
eGFR
1.017 (0.205, 1.830)
0.014
Switching dose
0.1304 (0.0022, 0.243)
0.019
Switching dose
48.2 (7.74, 88.66)
0.020
Baseline insulin
-0.143 (-0.277, -0.0089)
0.037
Baseline insulin
-52.24 (-101.28, -3.20)
0.037
Baseline sulfonylurea
-0.158 (-0.275, -0.0416)
0.008
Baseline sulfonylurea
-57.75 (-100.31, -15.19)
0.008
Injection history
0.0905 (-0.037, 0.219)
0.166
Injection history
32.92 (-13.99, 79.83)
0.168
Baseline neuropathy
0.1415 (-0.0145, 0.297)
0.075
Baseline neuropathy
51.57 (-5.44, 108.58)
0.076
Baseline obesity
-0.1453 (-0.300, 0.0094)
0.065
Baseline obesity
-53.02 (-109.54, 3.52)
0.066
PDC: proportion of days covered; eGFR: estimated glomerular filtration rate; CVD: cardiovascular disease; TG: triglyceride; value determined by the multivariate linear regression after variables were removed from the model using backward selection method.
