Huaju Xiaoji Formula Regulates ERS-lncMGC/miRNA to Enhance the Renal Function of Hypertensive Diabetic Mice with Nephropathy

Figure 3

HJXJ intervention reduced fibrosis in STZ-LNAME-induced mice after 12 weeks. (a) ELISA was performed to detect the level of TGFβ1, fibronectin, and laminin in the serum of HDN mice after 12 weeks of HJXJ intervention. (b) ELISA was performed to detect the level of TGFβ1, fibronectin, laminin, and collagen (COL I and COL IV) in the serum of HDN mice after 12 weeks of HJXJ intervention. (c) The mRNA level of α-SMA in the kidney tissue of HDN mice after 12 weeks of HJXJ intervention was evaluated by RT-qPCR. (d) Western blotting assays were performed to measure the level of α-SMA, Smad2/3, and p-smad2/3 in the kidney tissue of HDN mice after 12 weeks of HJXJ intervention. , vs. Con group; ^# and ^##, vs. STZ-LNAME group.

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