Journal of Diabetes Research

Vascular Stem and Progenitor Cells in Diabetic Complications


Publishing date
01 Apr 2012
Status
Published
Submission deadline
01 Oct 2011

1Division of Metabolic Diseases, Department of Clinical and Experimental Medicine, University of Padova, 35122 Padova, Italy

2Brigham and Women's Hospital, Transplantation Research Center, Boston, MA, USA

3Department of Physiology and Pharmacology, University of Bristol, Bristol, UK

4Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands


Vascular Stem and Progenitor Cells in Diabetic Complications

Description

Hyperglycemia and associated biochemical alterations damage vascular wall cells, especially the endothelium, leading to an increase risk of cardiovascular events. In the last decade, accumulating data suggest that vascular repair mechanisms are important to maintain normal homeostasis of the arterial wall and to prevent development of pathologic processes, such as atherosclerosis and restenosis. Diabetes, through impairment of vascular stem and progenitor cells, entails a defective repair of endothelial injury. The biochemical and cellular mechanisms that account for reduced or functionally impaired vascular progenitor cells in diabetes are not fully elucidated, and this is an intense area of research. Additionally, pharmacologic ways to favorably modulate endogenous reparative/regenerative processes are of particular interest in the setting of experimental and clinical diabetes research.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular and cellular aspects underlying defective vascular repair by means of stem/progenitor cells in diabetes, as well as development of interventions to reverse it. Additional areas of interest include -OMICs approaches, such as genomic-, proteomic-, or metabolomics-based discovery of new pathways in altered diabetic stem/progenitor cells.

We are particularly interested in articles describing new quantitative or qualitative aspects of vascular stem/progenitor cell defects in diabetes and modalities for reversal of these alterations by exploiting available therapeutic approaches or novel molecular targets, such as epigenetic regulators, microRNAs, and oxidative stress determinants. Potential topics include, but are not limited to:

  • Phenotypic specification of stem/progenitor cells affected by the diabetic state, with a specific focus on endothelial, smooth muscle, osteogenic, and adipogenic precursors
  • In vitro and in vivo strategies to reverse alterations of vascular progenitor cells in diabetes
  • New technologies to study vascular stem/progenitor cells in diabetes, at all levels, from flow cytometry to cell culture and in vivo tracking methods
  • Pharmacologic modulation of vascular stem/progenitor cells in the setting of diabetes
  • The role of inflammation and inflammatory pathways on diabetic vascular stem/progenitor cells
  • Relationships between aging and the diabetic milieu in inducing vascular progenitor cell defects, with focus on longevity determinant pathways (e.g., sirtuins, AMPK, and oxidative stress.)
  • In vivo models of vascular stem cell therapy for diabetic complications, both micro- and macrovascular

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jdr/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 580343
  • - Editorial

Vascular Stem and Progenitor Cells in Diabetic Complications

Gian Paolo Fadini | Paolo Madeddu | ... | Paolo Fiorina
  • Special Issue
  • - Volume 2012
  • - Article ID 728325
  • - Review Article

The Role of Angiogenesis in the Development of Proliferative Diabetic Retinopathy: Impact of Intravitreal Anti-VEGF Treatment

Gemma Tremolada | Claudia Del Turco | ... | Gianpaolo Zerbini
  • Special Issue
  • - Volume 2012
  • - Article ID 742976
  • - Review Article

It Is All in the Blood: The Multifaceted Contribution of Circulating Progenitor Cells in Diabetic Complications

Gian Paolo Fadini | Angelo Avogaro
  • Special Issue
  • - Volume 2012
  • - Article ID 916560
  • - Review Article

Regenerative Therapies for Diabetic Microangiopathy

Roberto Bassi | Alessio Trevisani | ... | Paolo Fiorina
  • Special Issue
  • - Volume 2012
  • - Article ID 274363
  • - Research Article

Amelioration of Glucose Control Mobilizes Circulating Pericyte Progenitor Cells in Type 2 Diabetic Patients with Microangiopathy

Gian Paolo Fadini | Patrizia Mancuso | ... | Angelo Avogaro
  • Special Issue
  • - Volume 2012
  • - Article ID 921685
  • - Research Article

Procalcific Phenotypic Drift of Circulating Progenitor Cells in Type 2 Diabetes with Coronary Artery Disease

Gian Paolo Fadini | Mattia Albiero | ... | Angelo Avogaro
  • Special Issue
  • - Volume 2012
  • - Article ID 471823
  • - Review Article

Strategies to Reverse Endothelial Progenitor Cell Dysfunction in Diabetes

Alessandra Petrelli | Raffaele Di Fenza | ... | Paolo Fiorina
  • Special Issue
  • - Volume 2012
  • - Article ID 585018
  • - Review Article

Dysfunctional Endothelial Progenitor Cells in Metabolic Syndrome

Sridevi Devaraj | Ishwarlal Jialal
  • Special Issue
  • - Volume 2012
  • - Article ID 518426
  • - Research Article

A PEDF-Derived Peptide Inhibits Retinal Neovascularization and Blocks Mobilization of Bone Marrow-Derived Endothelial Progenitor Cells

Richard Longeras | Krysten Farjo | ... | Jian-Xing Ma
  • Special Issue
  • - Volume 2012
  • - Article ID 872504
  • - Review Article

Cell-Based Therapies for Diabetic Complications

Stella Bernardi | Giovanni Maria Severini | ... | Paola Secchiero
Journal of Diabetes Research
 Journal metrics
Acceptance rate31%
Submission to final decision73 days
Acceptance to publication25 days
CiteScore3.020
Impact Factor3.040
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