Journal of Diabetes Research

The Unattended Borderline of Diabetic Neuropathy

Publishing date
01 Nov 2021
Submission deadline
09 Jul 2021

Lead Editor

1Semmelweis University, Budapest, Hungary

2Democritus University of Thrace, Thrace, Greece

3Szeged University, Szeged, Hungary

4University of Rome Tor Vergata, Rome, Italy

5Shupyk National Medical Academy Of Postgraduate Education, Kiev, Ukraine

This issue is now closed for submissions.

The Unattended Borderline of Diabetic Neuropathy

This issue is now closed for submissions.


The clinical and prognostic importance of diabetic neuropathy is still undervalued in diabetology. Nevertheless, this can be attributed to objective reasons as well. The diagnosis and treatment of nephropathy is clearly the domain of the internist and the diabetologist, whereas retinopathy is the responsibility of the ophthalmologist. However, neuropathy still remains an unattended borderline between the different domains of internal medicine and neurology. Indeed, diabetic neuropathy is an interdisciplinary subject, comprised of the related fields of urology, surgery, paediatrics, psychiatry, vascular surgery, and rehabilitation. The poor prognosis of cardiovascular autonomic neuropathy has been well known for about 40 years, and in recent decades it has become evident that sensorimotor neuropathy is also associated with poor outcome. Besides poor prognosis, the quality of life of patients with neural complications is severely impaired as well. Cardiovascular diseases including myocardial infarction and sudden death represent the main causes of death among diabetic patients. Silent myocardial infarction and ischaemia, major arrythmias, and sudden death are well-known manifestations of cardiovascular autonomic neuropathy.

This topic represents an interesting area in the field of cardiodiabetology, with deep gaps in our knowledge. It is much less well known that neuropathy is associated with anxiety, depression, frailty, and with a high risk of falling. Although there have been excellent experimental studies in the treatment of diabetic neuropathy, there has been no real progression in clinical practice for more than a decade. On the other hand, several new risk factors of neuropathy have been identified, raising the possibility for slowing down the progression of neuropathy. An important new area of research is the relationship between vitamin D supply and neuropathy. Among the gastrointestinal manifestations of neuropathy, the weak relationship between subjective symptoms and objective alterations still remains an open question. Little is known about neuropathy due to more etiological factors. As chronic renal diseases represent an independent predictor for the development and progression of neuropathy, more should be learned about neuropathy among patients with diabetic nephropathy.

The aim of this Special Issue is to collate original research articles with a focus on experimental and clinical neuropathy in the field of pathogenesis, diagnosis, and treatment. Review articles discussing the current state of the art are also welcomed.

Potential topics include but are not limited to the following:

  • Autonomic neuropathy
  • Sensory neuropathy
  • Combination therapy of diabetic neuropathy
  • New risk factors of neuropathy
  • Connection between vitamin D3 supply and neuropathy
  • Early death due to neuropathy
  • Early neuropathy among subjects with high risk for the development of prediabetes
  • Discrepancy between objective alterations and subjective symptoms of gastrointestinal neuropathy
  • Connection between neuropathy and mortality


  • Special Issue
  • - Volume 2021
  • - Article ID 6045677
  • - Research Article

Skin Advanced Glycation End Products among Subjects with Type 2 Diabetes Mellitus with or without Distal Sensorimotor Polyneuropathy

Stella Papachristou | Kalliopi Pafili | ... | Nikolaos Papanas
  • Special Issue
  • - Volume 2021
  • - Article ID 5593608
  • - Review Article

What Is in the Field for Genetics and Epigenetics of Diabetic Neuropathy: The Role of MicroRNAs

V. Spallone | C. Ciccacci | ... | P. Borgiani
  • Special Issue
  • - Volume 2021
  • - Article ID 6662159
  • - Research Article

Association of Cardiovascular Autonomic Neuropathy and Distal Symmetric Polyneuropathy with All-Cause Mortality: A Retrospective Cohort Study

Orsolya E. Vági | Márk M. Svébis | ... | Adam G. Tabák
  • Special Issue
  • - Volume 2021
  • - Article ID 9941791
  • - Research Article

Network Pharmacology and Molecular Docking Study on the Potential Mechanism of Yi-Qi-Huo-Xue-Tong-Luo Formula in Treating Diabetic Peripheral Neuropathy

Yixuan Lin | Chuqiao Shen | ... | Guoming Shen
  • Special Issue
  • - Volume 2021
  • - Article ID 5521493
  • - Research Article

Designing a Logistic Regression Model for a Dataset to Predict Diabetic Foot Ulcer in Diabetic Patients: High-Density Lipoprotein (HDL) Cholesterol Was the Negative Predictor

Seyyed Amir Yasin Ahmadi | Razieh Shirzadegan | ... | Mehrzad Jafarzadeh
Journal of Diabetes Research
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Acceptance rate10%
Submission to final decision127 days
Acceptance to publication19 days
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Impact Factor4.3

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