Journal of Diabetes Research

Diabetes Mellitus and its Cardiovascular Complications: New Insights into an Old Disease 2020


Publishing date
01 Dec 2020
Status
Closed
Submission deadline
24 Jul 2020

Lead Editor

1University of Campania “Luigi Vanvitelli”, Naples, Italy

2Temple University, Philadelphia, USA

3Columbia University, New York City, USA

4Medical University of Graz, Graz, Austria

This issue is now closed for submissions.
More articles will be published in the near future.

Diabetes Mellitus and its Cardiovascular Complications: New Insights into an Old Disease 2020

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Diabetes Mellitus (DM) is a worldwide social problem, with a high hospitalization rate and mortality. The American Heart Association considers DM as one of the seven major controllable risk factors for cardiovascular (CV) disease. In fact, DM is strongly associated with both micro-and macro-vascular complications, including retinopathy, nephropathy, and neuropathy as well as cerebrovascular disease, coronary artery disease (CAD), and peripheral artery disease (PAD). These hyperglycemia-induced pathological conditions may result in organ and tissue damage in one third to one half of diabetics.

In fact, diabetics are two to four times more likely to die from heart disease than non-diabetics. Regarding cardiovascular diseases, DM can negatively affect cardiac function, leading to the development of heart failure (HF). Intriguingly, in patients with HF and preserved HF (HFpEF), DM increases cardiomyocyte hypertrophy and cardiac inflammation, while in patients with HF and reduced EF (HFrEF), DM increases fibrosis and cardiomyocyte cell death. In both cases, DM is linked to higher mortality, reduced functional status, and increased risk of hospitalization.

In our Special Issue, new diagnostic tools for early detection of CV complications are welcome. Diabetic nephropathy, cardiomyopathy, or PAD are frequently diagnosed at later disease stages, and screening programs are inconsistent and inadequate. Diet, exercise training, and lifestyle changes may prevent or delay CV complications of DM. However, there is an urgent need to find new therapeutic approaches to blunt the systemic and tissue-specific effects of hyperglycemia and insulin resistance to reduce the development of diabetic CV complications. The final goal in the near future will be to find treatments better tailored to diabetic patients using a personalized–medicine approach. Therefore, we invite investigators to submit original research articles, reviews, or clinical trials to this Special Issue with the purpose of addressing the CV complications of diabetes.

Potential topics include but are not limited to the following:

  • New findings in the pathogenesis of micro- and macro-vascular complications in DM
  • New diagnostic tools for DM early diagnosis and its consequences: biomarkers and imaging
  • New therapeutic approaches for the CV consequences of DM: gene therapy, exosomes, miRNA, incretins, bioengineering approaches, etc.
  • Diabetes and atherosclerosis: CAD and PAD
  • Diabetic cardiomyopathy: different phenotypes and clinical outcomes
  • Heart failure in diabetics: diagnosis and treatment
  • Diabetes and its consequences during aging: multidimensional therapeutic approach
  • Hyperglycemia-induced systemic and tissue-specific damage
  • Exercise training and diabetic angiopathy
  • Clinical characteristics and outcomes of diabetic patients in different demographic and social settings

Articles

  • Special Issue
  • - Volume 2021
  • - Article ID 9676754
  • - Research Article

A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates

Xiu Wang | Shi Jin | Weina Hu
  • Special Issue
  • - Volume 2020
  • - Article ID 7181383
  • - Research Article

Early Diabetic Nephropathy and Retinopathy in Patients with Type 1 Diabetes Mellitus Attending Sudan Childhood Diabetes Centre

Hana Ahmed | Tayseer Elshaikh | Mohamed Abdullah
  • Special Issue
  • - Volume 2020
  • - Article ID 1942086
  • - Review Article

Calcium Homeostasis in Ventricular Myocytes of Diabetic Cardiomyopathy

Lina T. Al Kury
  • Special Issue
  • - Volume 2020
  • - Article ID 6976153
  • - Research Article

Type 2 Diabetes Mellitus and Chronic Heart Failure with Midrange and Preserved Ejection Fraction: A Focus on Serum Biomarkers of Fibrosis

D. A. Lebedev | E. A. Lyasnikova | ... | E. V. Shlyakhto
  • Special Issue
  • - Volume 2020
  • - Article ID 5316769
  • - Research Article

Combination of Composite Autonomic Symptom Score 31 and Heart Rate Variability for Diagnosis of Cardiovascular Autonomic Neuropathy in People with Type 2 Diabetes

Zhiyin Zhang | Yujin Ma | ... | Hongwei Jiang
  • Special Issue
  • - Volume 2020
  • - Article ID 7489795
  • - Review Article

Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications

Eleftheria Papachristoforou | Vaia Lambadiari | ... | Konstantinos Makrilakis
  • Special Issue
  • - Volume 2020
  • - Article ID 3854630
  • - Research Article

Association of Maternal Diabetes Mellitus and Polymorphisms of the NKX2.5 Gene in Children with Congenital Heart Disease: A Single Centre-Based Case-Control Study

Mingyi Zhao | Jingyi Diao | ... | Jiabi Qin
  • Special Issue
  • - Volume 2020
  • - Article ID 3069867
  • - Review Article

Prevalence of Cardiovascular Disease in Patients with Type 2 Diabetes Mellitus in Iran: A Systematic Review and Meta-Analysis

Mohsen Kazeminia | Nader Salari | Masoud Mohammadi
  • Special Issue
  • - Volume 2020
  • - Article ID 3634974
  • - Research Article

Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes

Qian Wang | Xuefei Tian | ... | Ping Li
  • Special Issue
  • - Volume 2020
  • - Article ID 7574245
  • - Research Article

Geranylgeranyl Transferase-I Knockout Inhibits Oxidative Injury of Vascular Smooth Muscle Cells and Attenuates Diabetes-Accelerated Atherosclerosis

Guo-Ping Chen | Jian Yang | ... | Xiao-Qin Zhang
Journal of Diabetes Research
 Journal metrics
Acceptance rate32%
Submission to final decision68 days
Acceptance to publication26 days
CiteScore4.900
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Impact Factor4.011
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Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.