Diabetes and its prevalence are growing constantly in the population worldwide. Development of tissue complications, predominantly microvascular and macrovascular disease (atherosclerosis) result from chronic diabetes.

Despite the advancement and improvement of diagnostic and therapeutic tools for cardiovascular assessment and treatment, patients with diabetes present a challenging group for those purposes. There is poorer prognosis in terms of outcomes, including survival due to various mechanisms. Diabetes is responsible for more advanced atherosclerosis in various vascular beds, dysfunction of coronary physiology including microcirculation. Moreover, due to more extensive and calcified atherosclerosis, more advanced devices are required to treat this subset of patients effectively (e.g., rotational atherectomy, intravascular lithotripsy). New drugs are being developed to sustain optimal long-term results of interventions.

The aim of this Special Issue is to bring together original research articles and review articles highlighting current data diagnostic variations (physiology, biomarkers, imaging) and therapy (conservative and invasive) in different settings of cardiovascular diseases and diabetes.

Potential topics include but are not limited to the following:

• Coronary physiology assessment in patients with diabetes
• Aortic valve stenosis and diabetes
• Treatment of resistant coronary artery disease in patients with diabetes
• Diabetes in patients with heart failure requiring mechanical support
• Reperfusion injury in myocardial infarction in patients with diabetes
• Renal injury in diabetic patients undergoing coronary revascularization
• Carotid artery interventions in diabetic patients
• Peripheral arterial revascularization in patients with diabetes
• Biomarkers of endothelial dysfunction and outcomes