Journal of Diabetes Research

Pathogenesis and Treatment of Diabetic Foot Ulcerations


Publishing date
01 Sep 2019
Status
Closed
Submission deadline
19 Apr 2019

Lead Editor

1University of Notre Dame, Indiana, USA

2Pharmacyclics, California, USA

This issue is now closed for submissions.
More articles will be published in the near future.

Pathogenesis and Treatment of Diabetic Foot Ulcerations

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Diabetic foot ulceration (DFU) is a serious complication of diabetes mellitus and the most common cause of hospitalization in diabetic patients. The development of a diabetic foot ulcer is principally related to the presence of peripheral neuropathy and foot deformities, often accompanied by peripheral arterial disease and various diabetes-related immunopathies. Several pathogenic abnormalities, ranging from disease-specific intrinsic flaws in blood supply, angiogenesis, and matrix turnover to extrinsic factors due to infection and continued trauma, contribute to failure to heal. Yet, despite these obstacles, there is increasing cause for optimism in the treatment of diabetic wounds. Enhanced understanding and correction of pathogenic factors, combined with stricter adherence to standards of care and with technological breakthroughs in biological agents, can be used to help develop new approaches to treat impaired healing.

We invite investigators to contribute original research articles that illustrate the mechanisms involved in the pathogenesis of DFU, identifying potential new targets for the treatment of DFU. Novel strategies for the prevention and treatment of DFU are highly encouraged. Finally, comprehensive reviews on these items will also be welcome.

Potential topics include but are not limited to the following:

  • The role of vasculopathy and endothelial cell abnormalities, neurodegeneration, and infection in the pathogenesis of DFU
  • Inflammation and oxidative stress in the development of DFU
  • Updated methods for in vivo metabolic assessment of the DFU
  • The relationship between DFU and glucose levels
  • New treatments of DFU based on antibacterial, anti-inflammation, and antioxidative stress
  • Diabetic drugs and their potential effect on DFU

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 3426878
  • - Research Article

Utility of Tetrahydrobiopterin Pathway in the Assessment of Diabetic Foot Ulcer: Significant and Complex Interrelations

Marwan Al-Nimer | Rawa Ratha | Taha Mahwi
  • Special Issue
  • - Volume 2019
  • - Article ID 9316380
  • - Clinical Study

Prospective Randomized Controlled Study of Hemostatic Efficacy with Kaolin-Impregnated Dressings in Diabetic Foot Ulcers Taking Anticoagulants Undergoing Debridement in an Outpatient Clinic

Yeok Gu Hwang | Jin Woo Lee | ... | Seung Hwan Han
  • Special Issue
  • - Volume 2019
  • - Article ID 5945839
  • - Research Article

The Superiority of Removable Contact Splints in the Healing of Diabetic Foot during Postoperative Care

Vladimíra Fejfarová | Jaroslav Pavlů | ... | Věra Lánská
  • Special Issue
  • - Volume 2019
  • - Article ID 5319892
  • - Research Article

Risk Factors and Diagnosis of Diabetic Foot Ulceration in Users of the Brazilian Public Health System

Hígor Chagas Cardoso | Ana Laura de Sene Amâncio Zara | ... | Fátima Mrué
  • Special Issue
  • - Volume 2019
  • - Article ID 6429575
  • - Research Article

Healing of Diabetic Foot Ulcers in Patients Treated at the Copenhagen Wound Healing Center in 1999/2000 and in 2011/2012

Marie Louise Buhl Sørensen | Rasmus Bo Jansen | ... | Ole Lander Svendsen
  • Special Issue
  • - Volume 2019
  • - Article ID 9696521
  • - Research Article

Notoginsenoside Fc Accelerates Reendothelialization following Vascular Injury in Diabetic Rats by Promoting Endothelial Cell Autophagy

Jingjing Liu | Chunyu Jiang | ... | Jianbo Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 4312737
  • - Research Article

Procalcitonin Is a Prognostic Marker of Hospital Outcomes in Patients with Critical Limb Ischemia and Diabetic Foot Infection

Marco Meloni | Valentina Izzo | ... | Luigi Uccioli
Journal of Diabetes Research
 Journal metrics
Acceptance rate31%
Submission to final decision71 days
Acceptance to publication25 days
CiteScore3.020
Impact Factor3.040
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