Journal of Diabetes Research

Mitochondria and Endoplasmic Reticulum in Diabetes and Its Complications


Publishing date
01 Feb 2012
Status
Published
Submission deadline
01 Aug 2011

Lead Editor

1Department of Internal Medicine, College of Medicine, University of Ulsan, Seoul, Republic of Korea

2Department of Biochemistry and Molecular Biology, School of Medicine, Indiana University, Indianapolis, IN, USA

3Departments of Internal Medicine and Biochemistry, School of Medicine, Kyungpook National University, Daegu, Republic of Korea

4Departments of Medicine and Ophthalmology, School of Medicine, Boston University, Boston, MA, USA


Mitochondria and Endoplasmic Reticulum in Diabetes and Its Complications

Description

Recent studies have provided evidence that mitochondrial dysfunction and endoplasmic reticulum (ER) stress are major pathogenic factors for diabetes and its complications. Mitochondria are the most important source of the chemical energy required by cells. Regulation of mitochondrial metabolism of glucose and fatty acids, the primary fuels used by cells to produce ATP, has been the subject of intensive research for several decades. In spite of this, much remains to be learned about tissue-specific fuel selection and the pathogenesis of diabetes and its complications. Cellular homeostasis also clearly depends upon the functional relationship between mitochondria and the ER. Propagation of calcium signaling from ER to mitochondria is involved in both ATP production and cell death. On the other hand, the ER requires ATP to function properly, which may make it the best site for sensing metabolic stress.

The goal of this special issue will be to clearly document the roles of mitochondrial dysfunction and ER stress in the pathogenesis of diabetes and its complications. The genesis of skeletal muscle insulin resistance, impaired hepatic glucose and lipid metabolism, beta-cell failure, and vascular dysfunction will be covered. Priority would be given to the regulation of mitochondrial metabolism of glucose and fatty acid, interaction between mitochondria and ER, and newer aspects of mitochondrial biology including mitochondrial biogenesis, mitochondrial dynamics (fission and fusion), and mitochondrial autophagy. Potential topics include, but are not limited to:

  • Roles of mitochondrial dysfunction and ER stress in the pathogenesis of diabetes, microvascular complications of diabetes, atherosclerosis, and nonalcoholic fatty liver disease
  • Tissue-specific fuel selection
  • Interaction between mitochondria and ER
  • Mitochondrial biogenesis, fission, fusion, or autophagy in diabetes
  • Metabolomics analysis

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jdr/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 985075
  • - Editorial

Mitochondria and Endoplasmic Reticulum in Diabetes and Its Complications

Ki-Up Lee | Robert A. Harris
  • Special Issue
  • - Volume 2012
  • - Article ID 481840
  • - Review Article

Endothelial Dysfunction in Diabetes Mellitus: Possible Involvement of Endoplasmic Reticulum Stress?

Basma Basha | Samson Mathews Samuel | ... | Hong Ding
  • Special Issue
  • - Volume 2012
  • - Article ID 939751
  • - Review Article

Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress

Bhaskar Ponugoti | Guangyu Dong | Dana T. Graves
  • Special Issue
  • - Volume 2012
  • - Article ID 696215
  • - Review Article

Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress

Alba Naudi | Mariona Jove | ... | Reinald Pamplona
  • Special Issue
  • - Volume 2012
  • - Article ID 642038
  • - Review Article

Mitochondrial Dysregulation in the Pathogenesis of Diabetes: Potential for Mitochondrial Biogenesis-Mediated Interventions

Anna-Maria Joseph | Denis R. Joanisse | ... | David A. Hood
  • Special Issue
  • - Volume 2012
  • - Article ID 827971
  • - Review Article

Endoplasmic Reticulum Stress and Diabetic Cardiomyopathy

Jiancheng Xu | Qi Zhou | ... | Lu Cai
  • Special Issue
  • - Volume 2012
  • - Article ID 703538
  • - Review Article

Mitochondrial Dysfunction and β-Cell Failure in Type 2 Diabetes Mellitus

Zhongmin Alex Ma | Zhengshan Zhao | John Turk
  • Special Issue
  • - Volume 2012
  • - Article ID 628978
  • - Review Article

Autophagy as a Therapeutic Target in Diabetic Nephropathy

Yuki Tanaka | Shinji Kume | ... | Daisuke Koya
  • Special Issue
  • - Volume 2012
  • - Article ID 639762
  • - Review Article

Guards and Culprits in the Endoplasmic Reticulum: Glucolipotoxicity and β-Cell Failure in Type II Diabetes

Udayakumar Karunakaran | Han-Jong Kim | ... | In-Kyu Lee
  • Special Issue
  • - Volume 2012
  • - Article ID 618396
  • - Review Article

Endoplasmic Reticulum Stress in the β-Cell Pathogenesis of Type 2 Diabetes

Sung Hoon Back | Sang-Wook Kang | ... | Hun-Taeg Chung
Journal of Diabetes Research
 Journal metrics
Acceptance rate31%
Submission to final decision73 days
Acceptance to publication25 days
CiteScore3.020
Impact Factor3.040
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