Journal of Diabetes Research

The Role of Oxidative Stress in the Development of Diabetes Mellitus and its Complications


Publishing date
01 May 2019
Status
Published
Submission deadline
21 Dec 2018

1Henry Ford College, Dearborn, USA

2King George Medical University, Lucknow, India

3University College Dublin, Dublin, Ireland


The Role of Oxidative Stress in the Development of Diabetes Mellitus and its Complications

Description

Oxidative stress is an imbalance in cellular redox reactions that play a key role in metabolic disorders including obesity, metabolic syndrome, and diabetes mellitus. Oxidative stress is the result of reactive oxygen species (ROS) overproduction or a decline in antioxidant defense mechanisms. Although ROS production can be beneficial in some cases as they are used by the immune system and cell communications, overall excessive generation of ROS results in deleterious effects causing damage to DNA, proteins, and lipids, ultimately leading to cell death. Therefore, agents counteracting excess ROS and/or increasing the antioxidant defenses represent an appealing strategy for the treatment of diabetes and its complications.

The current understanding of the complex role of ROS is necessary for developing multifunctional antioxidants, which can maintain oxidative homeostasis in diabetes. In this context, numerous research groups have focused on the characterization of the ROS source and the pathway triggered by ROS diabetes. In addition, a great deal of effort is being conducted to design and synthesize free radical scavenging and antioxidant substances that can diminish excessive ROS production and improve the endogenous antioxidant defenses in diabetes.

We invite investigators to contribute original research as well as review articles that illustrate the role of ROS in the development of diabetes and its complications. In addition, the purpose of the special issue will be to focus on articles describing the mechanism underlying the modulatory effect antioxidants have on oxidative stress.

Potential topics include but are not limited to the following:

  • Role of ROS in insulin resistance and diabetes complications
  • Nutrition, exercise, and the environment link on ROS generation and its implications in diabetes
  • In vitro and in vivo studies on the role of antioxidants in controlling redox imbalance and its implications in diabetes development and its complications
  • Modulators of the redox-sensitive transcription factors in diabetes
  • Natural and synthetic antioxidants as modulators of cellular signaling and metabolism in diabetes
  • Therapeutic application of antioxidants in oxidative stress related to diabetes

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 4189813
  • - Editorial

The Role of Oxidative Stress in the Development of Diabetes Mellitus and Its Complications

Julia M. Dos Santos | Shikha Tewari | Roberta H. Mendes
  • Special Issue
  • - Volume 2019
  • - Article ID 2981705
  • - Research Article

Effect of Baoshenfang Formula on Podocyte Injury via Inhibiting the NOX-4/ROS/p38 Pathway in Diabetic Nephropathy

Fang-qiang Cui | Long Tang | ... | Wei Jing Liu
  • Special Issue
  • - Volume 2019
  • - Article ID 1602892
  • - Research Article

Astragalus membranaceus and Panax notoginseng, the Novel Renoprotective Compound, Synergistically Protect against Podocyte Injury in Streptozotocin-Induced Diabetic Rats

Ruonan Zhai | Guihua Jian | ... | Dingkun Gui
  • Special Issue
  • - Volume 2019
  • - Article ID 9489826
  • - Review Article

Myocardial Ischemia and Diabetes Mellitus: Role of Oxidative Stress in the Connection between Cardiac Metabolism and Coronary Blood Flow

Paolo Severino | Andrea D’Amato | ... | Francesco Fedele
  • Special Issue
  • - Volume 2019
  • - Article ID 2583047
  • - Research Article

A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1

Zhen Zhang | Yinghui Hu | ... | Hong Chen
  • Special Issue
  • - Volume 2019
  • - Article ID 7457295
  • - Review Article

Evidence in Practice of Tissue Healing with Latex Biomembrane: Integrative Review

Suélia de Siqueira Rodrigues Fleury Rosa | Mário Fabrício Fleury Rosa | ... | Von Braun Richter
  • Special Issue
  • - Volume 2019
  • - Article ID 9426014
  • - Research Article

Glucagon-Like Peptide-1 Receptor Agonist Protects Dorsal Root Ganglion Neurons against Oxidative Insult

Mohammad Sarif Mohiuddin | Tatsuhito Himeno | ... | Hideki Kamiya
  • Special Issue
  • - Volume 2019
  • - Article ID 4858740
  • - Research Article

Effects of High-Fat Diet on eHSP72 and Extra-to-Intracellular HSP70 Levels in Mice Submitted to Exercise under Exposure to Fine Particulate Matter

Iberê Machado Kostrycki | Guilherme Wildner | ... | Thiago Gomes Heck
  • Special Issue
  • - Volume 2018
  • - Article ID 3274084
  • - Research Article

Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5

Pu Wang | Yu Cheng Lu | ... | Shao Chin Lee
Journal of Diabetes Research
 Journal metrics
Acceptance rate31%
Submission to final decision74 days
Acceptance to publication25 days
CiteScore3.020
Impact Factor3.040
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