Journal of Diabetes Research

Diabetes Mellitus and Its Cardiovascular Complications: New Insights into an Old Disease


Publishing date
01 Jan 2019
Status
Published
Submission deadline
17 Aug 2018

Lead Editor

1University of Campania “Luigi Vanvitelli”, Naples, Italy

2Temple University, Philadelphia, USA

3Columbia University, New York, USA

4Medical University of Graz, Graz, Austria


Diabetes Mellitus and Its Cardiovascular Complications: New Insights into an Old Disease

Description

Diabetes mellitus (DM) is a worldwide problem with a social impact, characterized by a high hospitalization rate and mortality. The American Heart Association considers DM as one of the seven major controllable risk factors for cardiovascular (CV) diseases. In fact, DM is strongly associated with both micro- and macrovascular complications, including retinopathy, nephropathy, and neuropathy, as well as cerebrovascular disease, coronary artery disease (CAD), and peripheral artery disease (PAD). These hyperglycemia-induced pathological conditions may result in organ and tissue damage in one-third to one-half of diabetics. In fact, diabetics are two to four times more likely to die from heart diseases than nondiabetics. Regarding cardiovascular diseases, DM can negatively affect the cardiac function, leading to the development of heart failure (HF). Intriguingly, in patients with HF and preserved HF (HFpEF), DM increases cardiomyocyte hypertrophy and cardiac inflammation, whereas in patients with HF and reduced EF (HFrEF), DM increases fibrosis and cardiomyocyte cell death. In both cases, DM is linked to higher mortality, reduced functional status, and increased risk of hospitalization.

In this special issue, new diagnostic tools for early detection of CV complications are welcome. Diabetic nephropathy, cardiomyopathy, and PAD are frequently diagnosed at later disease stages, and screening programs are inconsistent and inadequate. Diet, exercise training, and lifestyle changes may prevent or delay CV complications of DM. However, there is an urgent need to find new therapeutic approaches to blunt the systemic and tissue-specific effects of hyperglycemia and insulin resistance, to reduce the development of diabetic CV complications. The final goal in the near future will be to find treatments better tailored to diabetic patients using a personalized-medicine approach. Therefore, we invite investigators to submit original research articles, reviews, and clinical studies to this special issue having the purpose of addressing the CV complications of diabetes.

Potential topics include but are not limited to the following:

  • New findings in the pathogenesis of the micro- and macrovascular complications in DM
  • New diagnostic tools for DM early diagnosis and its consequences: biomarkers and imaging
  • New therapeutic approaches for the CV consequences of DM: gene therapy, exosomes, miRNA, incretins, bioengineering approaches, and so forth
  • Diabetes and atherosclerosis: CAD and PAD
  • Diabetic cardiomyopathy: different phenotypes and clinical outcomes
  • Heart failure in diabetics: diagnosis and treatment
  • Diabetes and its consequences during aging: multidimensional therapeutic approach
  • Hyperglycemia-induced systemic and tissue-specific damage
  • Exercise training and diabetic angiopathy
  • Clinical characteristics and outcomes of diabetic patients in different demographic and social settings

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 1905194
  • - Editorial

Diabetes Mellitus and Its Cardiovascular Complications: New Insights into an Old Disease

Celestino Sardu | Claudio De Lucia | ... | Gaetano Santulli
  • Special Issue
  • - Volume 2019
  • - Article ID 5157024
  • - Research Article

The Role of the Autonomic Nervous System on Cardiac Rhythm during the Evolution of Diabetes Mellitus Using Heart Rate Variability as a Biomarker

Alondra Albarado-Ibañez | Rosa Elena Arroyo-Carmona | ... | Julián Torres-Jácome
  • Special Issue
  • - Volume 2019
  • - Article ID 1365162
  • - Research Article

Predictors of Effectiveness of Glucagon-Like Peptide-1 Receptor Agonist Therapy in Patients with Type 2 Diabetes and Obesity

Alina Yu. Babenko | Daria A. Savitskaya | ... | Evgeny V. Shlyakhto
  • Special Issue
  • - Volume 2019
  • - Article ID 2591709
  • - Research Article

Does Body Mass Index and Height Influence the Incident Risk of Ischemic Stroke in Newly Diagnosed Type 2 Diabetes Subjects?

Donghui Duan | Hui Li | ... | Liyuan Han
  • Special Issue
  • - Volume 2018
  • - Article ID 9242579
  • - Research Article

Early Subclinical Atherosclerosis in Gestational Diabetes: The Predictive Role of Routine Biomarkers and Nutrigenetic Variants

Marica Franzago | Federica Fraticelli | ... | Ester Vitacolonna
  • Special Issue
  • - Volume 2018
  • - Article ID 4028297
  • - Research Article

L-Carnitine: An Antioxidant Remedy for the Survival of Cardiomyocytes under Hyperglycemic Condition

Fernanda Vacante | Pamela Senesi | ... | Ileana Terruzzi
  • Special Issue
  • - Volume 2018
  • - Article ID 5205126
  • - Review Article

Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications

Alina Mihaela Leustean | Manuela Ciocoiu | ... | Daniela Maria Tanase
  • Special Issue
  • - Volume 2018
  • - Article ID 3407306
  • - Review Article

The Impact of Obesity on the Cardiovascular System

Imre Csige | Dóra Ujvárosy | ... | Sándor Somodi
  • Special Issue
  • - Volume 2018
  • - Article ID 4603087
  • - Research Article

The U-Shaped Association between Bilirubin and Diabetic Retinopathy Risk: A Five-Year Cohort Based on 5323 Male Diabetic Patients

Miao Liu | Jianhua Wang | Yao He
  • Special Issue
  • - Volume 2018
  • - Article ID 3106056
  • - Review Article

Role of Tight Glycemic Control during Acute Coronary Syndrome on CV Outcome in Type 2 Diabetes

Ferdinando Carlo Sasso | Luca Rinaldi | ... | Raffaele Marfella
Journal of Diabetes Research
 Journal metrics
Acceptance rate32%
Submission to final decision92 days
Acceptance to publication31 days
CiteScore3.020
Impact Factor3.040
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