Membrane-bound organelles, such as mitochondria, endoplasmic reticulum (ER), lysosomes and peroxisomes create distinct cellular environments to perform specific functions in cell – for instance, energy production, protein synthesis and transport, and lipid breakdown. It is generally accepted that the dysfunction of cellular organelles dysfunction is related to type II diabetes mellitus (T2DM) in humans.

The link between mitochondria dysfunction and T2DM has been studied widely. The mitochondria are involved in active and dynamic processes, such as mitochondrial biogenesis, fission, fusion, and mitophagy to maintain energy balance. Reduced mitochondrial contents, lowered rates of oxidative phosphorylation, or excessive reactive oxygen species (ROS) production that are caused by the dysregulation of mitochondria function contribute to T2DM. Thus, it would be of great importance to study the organelle function in the pathogenesis of obesity and diabetes in different cell or animal models, and investigate the regulatory pathways that are deregulated or probe for new targets of disease treatment in the future.

This Special Issue aims to summarize the recent research achievements in the field of organelle function and regulation, and dysregulation of organelle function in obesity and diabetes. We welcome both original research and review articles.

Potential topics include but are not limited to the following:

• Dysregulation of organelle function in obesity and diabetes
• Cell or animal models for studying of organelle function in obesity and diabetes
• Organelle interactions and their dysregulation in obesity and diabetes
• New tools to investigate or visualize organelle function
• Clinical-related studies of organelle function in diseases