Journal of Diabetes Research

Animal Models of Diabetes and Metabolic Disease 2014


Status
Published

Lead Editor

1Central Pharmaceutical Research Institute, Osaka, Japan

2Kobe University, Kobe, Japan

3Harvard Medical School, Boston, USA

4CLEA Japan, Inc., Tokyo, Japan


Animal Models of Diabetes and Metabolic Disease 2014

Description

Metabolic diseases including diabetes (and its complications), obesity, dyslipidemia, and hypertension are common diseases and frequently occur in combination. To study these diseases, many hereditary animal models have been reported, such as ob/ob mice, db/db mice, KK-Ay mice, Goto-Kakizaki (GK) rats, Zucker diabetic fatty (ZDF) rats, Otsuka Long-Evans Tokushima-fatty (OLETF) rats, spontaneously diabetic Torii (SDT) rats, spontaneously hypertensive rats (SHR), Watanabe heritable hyperlipidemic (WHHL) rabbits, and postprandial hypertriglyceridemia (PHT) rabbits. Chemical (e.g., streptozotocin (STZ) and alloxan) and diet (e.g., high sucrose, high fat, and high cholesterol) induced experimental animal models have been used generally for a long time, and genetically modified animals have also been used widely in recent decades. Although molecular biological techniques have become more important to clarify the mechanism of the diseases, the importance of animal model has not changed. The animal models are needed to reveal the pathophysiology of metabolic diseases, and the approach still provides helpful information to develop new therapies and drugs for these diseases. In this special issue, we aim at providing information on recent beneficial experimental animal models in this field, and up-to-date information on the pathophysiology, therapeutic drugs, and diagnosis of metabolic diseases using valuable animal models is also welcome.

We invite investigators to contribute original research as well as review articles that will stimulate the continuing efforts towards understanding the pathophysiology, developing new drugs, and creating new approaches to treat these diseases. We are particularly interested in articles that describe the recently developed experimental animal models, of both hereditary and genetically modified types. Comparing or suggesting the best models for each disease is also encouraged.

Potential topics include, but are not limited to:

  • Animal models to evaluate and understand the pathophysiology of diabetes and other metabolic diseases
  • New aspects of animal models to treat metabolic syndrome
  • Pathophysiology and interventional studies of diabetes, obesity, dyslipidemia, arteriosclerosis, and hypertension using animal models
  • Recent advances in treating diabetes and its complications from nonclinical studies

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 571809
  • - Editorial

Animal Models of Diabetes and Metabolic Disease 2014

Tomohiko Sasase | Norihide Yokoi | ... | Masami Shinohara
  • Special Issue
  • - Volume 2015
  • - Article ID 487816
  • - Research Article

Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes

Richard G. Peterson | Charles V. Jackson | ... | Michael K. Hansen
  • Special Issue
  • - Volume 2015
  • - Article ID 261418
  • - Research Article

Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat

Ghupurjan Gheni | Norihide Yokoi | ... | Susumu Seino
  • Special Issue
  • - Volume 2015
  • - Article ID 731434
  • - Review Article

Beneficial Effects of Omega-3 Polyunsaturated Fatty Acids in Gestational Diabetes: Consequences in Macrosomia and Adulthood Obesity

Akadiri Yessoufou | Magloire P. Nekoua | ... | Kabirou Moutairou
  • Special Issue
  • - Volume 2014
  • - Article ID 629016
  • - Research Article

Ocular Inflammation in Uveal Tract in Aged Obese Type 2 Diabetic Rats (Spontaneously Diabetic Torii Fatty Rats)

Yusuke Kemmochi | Katsuhiro Miyajima | ... | Akihiro Kakehashi
  • Special Issue
  • - Volume 2014
  • - Article ID 672590
  • - Research Article

Effect of Ranirestat, a New Aldose Reductase Inhibitor, on Diabetic Retinopathy in SDT Rats

Fumihiko Toyoda | Yoshiaki Tanaka | ... | Akihiro Kakehashi
  • Special Issue
  • - Volume 2014
  • - Article ID 526972
  • - Research Article

Evaluating the Mechanisms of Improved Glucose Homeostasis after Bariatric Surgery in Ossabaw Miniature Swine

Jonathan G. Sham | Vlad V. Simianu | ... | David R. Flum
  • Special Issue
  • - Volume 2014
  • - Article ID 398518
  • - Research Article

Expression of CTRP3, a Novel Adipokine, in Rats at Different Pathogenic Stages of Type 2 Diabetes Mellitus and the Impacts of GLP-1 Receptor Agonist on It

Xin Li | Li Jiang | ... | Jia-zhong Sun
  • Special Issue
  • - Volume 2014
  • - Article ID 363126
  • - Research Article

Effects of Unilateral Nephrectomy on Renal Function in Male Spontaneously Diabetic Torii Fatty Rats: A Novel Obese Type 2 Diabetic Model

Yoshiaki Katsuda | Yusuke Kemmochi | ... | Takeshi Ohta
  • Special Issue
  • - Volume 2014
  • - Article ID 680348
  • - Research Article

Pharmacological Effects of JTT-551, a Novel Protein Tyrosine Phosphatase 1B Inhibitor, in Diet-Induced Obesity Mice

Makoto Ito | Sumiaki Fukuda | ... | Takeshi Ohta
Journal of Diabetes Research
 Journal metrics
Acceptance rate31%
Submission to final decision74 days
Acceptance to publication25 days
CiteScore3.020
Impact Factor3.040
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