Journal of Diabetes Research

Micro- and Macrovascular Complications in Diabetes Mellitus: Preclinical and Clinical Studies


Publishing date
01 Sep 2018
Status
Published
Submission deadline
27 Apr 2018

1Federal University of São Paulo, São Paulo, Brazil

2University of Miami, Miami, USA


Micro- and Macrovascular Complications in Diabetes Mellitus: Preclinical and Clinical Studies

Description

Diabetes mellitus (DM) is a worldwide public health problem that affects millions of people from all age, gender, racial, and ethnic groups. Diabetic nephropathy is the leading cause of chronic kidney disease (CKD). Likewise, DM is the leading cause of blindness and amputation and contributes substantially to cardiomyopathy and cerebrovascular and peripheral artery diseases. CKD is incurable, requiring renal replacement therapy, that is, dialysis or preferably renal transplantation. Simultaneous pancreas-kidney transplantation (SPKT) or pancreas after kidney (PAK) transplantation has revolutionized the way we manage type 1 DM and selected cases of type 2 DM with CKD; it provides a physiological means of achieving normoglycemia while rendering patients free of dialysis. Kidney transplant alone (KTA) leads also to better patient survival during long follow-up. However, the critical shortage of available organs for transplantation continues to severely limit this option, underlying the importance of novel therapeutic regimens to bypass these problems, such as stem cell therapy, which represents another source of cells for tissue regeneration. Additionally, recent advances in biology and medicine have also introduced new technologies to study the molecular pathology underlying DM-related complications, the development of novel strategies to treat these conditions, and the evaluation of outcomes.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to develop novel drugs and therapeutic targets and new perspectives of combined therapies for decreasing micro- and macrovascular complications in DM. We are particularly interested in articles describing the advances in molecular pathology and molecular diagnostics; new insights into DM-related complications using animal models; current concepts in the treatment of DM using drugs, nanoparticles, siRNA, stem cells and microvesicles, and viral and nonviral gene therapy strategies; outcomes and clinical benefits of pharmacologic/nonpharmacologic therapies and of transplant (SPKT, PAK, and KTA) that provide better care to patients.

Potential topics include but are not limited to the following:

  • Recent developments in micro- and macrovascular complications in DM research
  • Advances in pharmacologic and nonpharmacologic therapies to treat those conditions
  • Latest technologies for clinical evaluation and measuring outcomes
  • DM-related complications using animal models
  • Recent advances in cellular and molecular therapies to treat DM-related complications
  • Role of modifiers in DM-related complications after transplant

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 2161085
  • - Editorial

Micro- and Macrovascular Complications in Diabetes Mellitus: Preclinical and Clinical Studies

Érika B. Rangel | Cláudia O. Rodrigues | João R. de Sá
  • Special Issue
  • - Volume 2018
  • - Article ID 1631263
  • - Research Article

Retinopathy, Neuropathy, and Subsequent Cardiovascular Events in Patients with Type 2 Diabetes and Acute Coronary Syndrome in the ELIXA: The Importance of Disease Duration

Jelena P. Seferovic | Rhonda Bentley-Lewis | ... | Marc A. Pfeffer
  • Special Issue
  • - Volume 2018
  • - Article ID 6807219
  • - Research Article

Potent Oral Hypoglycemic Agents for Microvascular Complication: Sodium-Glucose Cotransporter 2 Inhibitors for Diabetic Retinopathy

Eun Hyung Cho | Se-Jun Park | ... | Yoo-Ri Chung
  • Special Issue
  • - Volume 2018
  • - Article ID 7926473
  • - Research Article

There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients

Mariana Nogueira Coutinho | Aluizio Barbosa Carvalho | ... | Maria Eugênia Fernandes Canziani
  • Special Issue
  • - Volume 2018
  • - Article ID 1390418
  • - Research Article

Artificially Cultivated Ophiocordyceps sinensis Alleviates Diabetic Nephropathy and Its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation

Chao Wang | Xiao-xia Hou | ... | Yi-Pu Chen
  • Special Issue
  • - Volume 2018
  • - Article ID 1054192
  • - Research Article

Polymorphisms in the Glucagon-Like Peptide 1 Receptor (GLP-1R) Gene Are Associated with the Risk of Coronary Artery Disease in Chinese Han Patients with Type 2 Diabetes Mellitus: A Case-Control Study

Xiaowei Ma | Ran Lu | ... | Xiaohui Guo
  • Special Issue
  • - Volume 2018
  • - Article ID 9817308
  • - Research Article

Distribution of Microbes and Drug Susceptibility in Patients with Diabetic Foot Infections in Southwest China

Mingxia Wu | Hang Pan | ... | Ziwen Liang
  • Special Issue
  • - Volume 2018
  • - Article ID 5182606
  • - Research Article

Renal Ischemia-Reperfusion Injury in a Diabetic Monkey Model and Therapeutic Testing of Human Bone Marrow-Derived Mesenchymal Stem Cells

Kyo Won Lee | Tae Min Kim | ... | Sung Joo Kim
  • Special Issue
  • - Volume 2018
  • - Article ID 7678310
  • - Research Article

Insoles Treated with Bacteria-Killing Nanotechnology Bio-Kil Reduce Bacterial Burden in Diabetic Patients and Healthy Controls

Difei Lu | Xiaohui Guo | ... | Junqing Zhang
  • Special Issue
  • - Volume 2018
  • - Article ID 7806435
  • - Review Article

Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications

Bou-Yue Peng | Navneet Kumar Dubey | ... | Hong-Jian Wei
Journal of Diabetes Research
 Journal metrics
Acceptance rate31%
Submission to final decision73 days
Acceptance to publication25 days
CiteScore3.020
Impact Factor3.040
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