Journal of Diabetes Research

Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis


Publishing date
16 Oct 2015
Status
Published
Submission deadline
29 May 2015

Lead Editor

1University of Louisville, Louisville, USA

2Fujian Medical University, Fujian, China

3Baker IDI Heart and Diabetes Institute, Melbourne, Australia

4King's College London, London, UK


Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis

Description

Diabetic nephropathy is the largest single cause of end-stage renal disease (ESRD). It starts from microalbuminuria, an increased leakage of proteins into urine, and ends with renal failure, the building up of toxic waste in blood requiring dialysis or kidney transplantation. This process takes nearly 10 to 20 years to develop and occurs in about 20% of patients with diabetes. Hyperglycemia and the relevant metabolic disorders in diabetes can induce oxidative stress and inflammatory response in the body and the kidney in particular, eventually resulting in kidney fibrosis and the loss of function. Many molecules and pathways have been linked to contributing to renal damage. However, due to the complexity of diabetic nephropathy, there is no complete understanding of this devastating disease. Identifying novel biomarkers for early diagnosis and novel target(s) for treatment to prevent or slow the progression of renal damage in diabetics are a big challenge.

In this special issue of the Journal of Diabetes Research, we are inviting authors to submit original research papers as well as review articles to discuss the current understanding of cellular and molecular pathology, function, and signal pathways in diabetic nephropathy. We are also interested in manuscripts that report the advances in diagnosis or treatment of diabetic nephropathy.

Potential topics include, but are not limited to:

  • Proteinuria in diabetic nephropathy: molecular and pathological basis
  • In vivo and in vitro studies on podocyte, vascular endothelium, and tubular cell damage
  • Oxidative stress and inflammation in diabetic kidney
  • Fibrosis, what is the major driving factor?
  • New pathway in diabetic nephropathy
  • Novel approach to prevent or treat diabetic nephropathy

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 5241549
  • - Editorial

Diabetic Nephropathy: Proteinuria, Inflammation, and Fibrosis

Shirong Zheng | David W. Powell | ... | Luigi Gnudi
  • Special Issue
  • - Volume 2016
  • - Article ID 3537863
  • - Research Article

Influence of Acute High Glucose on Protein Abundance Changes in Murine Glomerular Mesangial Cells

Michelle T. Barati | James C. Gould | ... | Michael L. Merchant
  • Special Issue
  • - Volume 2016
  • - Article ID 1841690
  • - Review Article

Immune Cells and Inflammation in Diabetic Nephropathy

Zihan Zheng | Feng Zheng
  • Special Issue
  • - Volume 2016
  • - Article ID 5362506
  • - Research Article

Renal Protection by Genetic Deletion of the Atypical Chemokine Receptor ACKR2 in Diabetic OVE Mice

Shirong Zheng | Susan Coventry | ... | Paul N. Epstein
  • Special Issue
  • - Volume 2016
  • - Article ID 7934504
  • - Review Article

A Systems Biology Overview on Human Diabetic Nephropathy: From Genetic Susceptibility to Post-Transcriptional and Post-Translational Modifications

Francesca Conserva | Loreto Gesualdo | Massimo Papale
  • Special Issue
  • - Volume 2016
  • - Article ID 2315260
  • - Research Article

Association of Haemostatic and Inflammatory Biomarkers with Nephropathy in Type 1 Diabetes Mellitus

Caroline Pereira Domingueti | Rodrigo Bastos Fóscolo | ... | Ana Paula Fernandes
  • Special Issue
  • - Volume 2016
  • - Article ID 5749857
  • - Review Article

Review of Herbal Traditional Chinese Medicine for the Treatment of Diabetic Nephropathy

Guang-dong Sun | Chao-yuan Li | ... | Li-ning Miao
Journal of Diabetes Research
 Journal metrics
Acceptance rate34%
Submission to final decision85 days
Acceptance to publication27 days
CiteScore3.020
Impact Factor3.040
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