Journal of Diabetes Research

Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications 2015


Publishing date
26 Jun 2015
Status
Published
Submission deadline
06 Feb 2015

1University of Saskatchewan, Saskatoon, Canada

2The Henry Ford Heart and Vascular Institute, Detroit, USA

3University of Florence, Florence, Italy


Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications 2015

Description

The global escalation of obesity and diabetes in developed and developing nations poses a great health challenge. Obesity is one of the major causes of type 2 diabetes. Type 1 diabetes is primarily due to the autoimmune-mediated destruction of pancreatic beta-cell leading to insulin deficiency. This is usually accompanied by alterations in lipid metabolism, enhanced hyperglycemia-mediated oxidative stress, endothelial cell dysfunction, and apoptosis. Similarly, in type 2 diabetes, increased glucotoxicity, lipotoxicity, endoplasmic reticulum-induced stress, and apoptosis lead to the progressive loss of beta-cells. While type 1 diabetes is characterized by the presence of beta-cell autoantibodies, a combination of peripheral insulin resistance and dysfunctional insulin secretion by pancreatic beta-cells is implicated in the pathogenesis of type 2 diabetes. Although insulin resistance has traditionally been associated with type 2 diabetes, mounting evidence indicates that the incidence of insulin resistance in type 1 diabetes is increasing; therefore, novel mechanistic approaches deciphering insulin resistance are needed. Many pathophysiological factors are implicated in insulin resistance. Although the exact natures of these factors are not completely understood, it is widely accepted that oxidative stress, inflammation, and genetic, habitual, environmental, and other epigenetic factors play a significant role.

In the past decade, significant strides have been made in elucidating important mechanisms associated with insulin resistance, overt diabetes, and related cardiometabolic diseases. However, more intense research is still needed for a more comprehensive understanding of the pathophysiological profile of insulin resistance in diabetes, especially in situations where diabetes is comorbid with other chronic diseases.

Therefore, this special issue will welcome research and review papers that address a broad range of mechanisms associated with insulin resistance, type 1 diabetes, type 2 diabetes, and related cardiometabolic complications.

Potential topics include, but are not limited to:

  • Role of epigenetics in type 1 and type 2 diabetes
  • Novel mechanisms of insulin resistance and dysfunctional glucose metabolism in type 1 and type 2 diabetes
  • Novel prognostic and therapeutic interventions
  • Role of adiposity in insulin signaling and cardiometabolic complications
  • Macrovascular and microvascular complications of diabetic complications including cardiomyopathy, nephropathy, vasculopathy, and neuropathy

Articles

  • Special Issue
  • - Volume 2015
  • - Article ID 234135
  • - Editorial

Insulin Resistance, Type 1 and Type 2 Diabetes, and Related Complications 2015

Joseph Fomusi Ndisang | Sharad Rastogi | Alfredo Vannacci
  • Special Issue
  • - Volume 2015
  • - Article ID 616747
  • - Research Article

NLRP3 Inflammasome Polymorphism and Macrovascular Complications in Type 2 Diabetes Patients

Jasna Klen | Katja Goričar | ... | Vita Dolžan
  • Special Issue
  • - Volume 2015
  • - Article ID 760535
  • - Research Article

Edible Bird’s Nest Prevents High Fat Diet-Induced Insulin Resistance in Rats

Zhang Yida | Mustapha Umar Imam | ... | Norhayati Binti Yusuf
  • Special Issue
  • - Volume 2015
  • - Article ID 362375
  • - Review Article

Population-Based Studies on the Epidemiology of Insulin Resistance in Children

M. P. van der Aa | S. Fazeli Farsani | ... | M. M. J. van der Vorst
  • Special Issue
  • - Volume 2015
  • - Article ID 129695
  • - Research Article

Association of the Genetic Polymorphisms in Transcription Factor 7-Like 2 and Peroxisome Proliferator-Activated Receptors-γ2 with Type 2 Diabetes Mellitus and Its Interaction with Obesity Status in Emirati Population

Habiba Al-Safar | Ahmed Hassoun | ... | Naushad Rais
  • Special Issue
  • - Volume 2015
  • - Article ID 490842
  • - Review Article

GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective

Ramu Adela | Sanjay K. Banerjee
  • Special Issue
  • - Volume 2015
  • - Article ID 943659
  • - Research Article

MicroRNA-223 Expression Is Upregulated in Insulin Resistant Human Adipose Tissue

Tung-Yueh Chuang | Hsiao-Li Wu | ... | Yen-Hao Chen
  • Special Issue
  • - Volume 2015
  • - Article ID 783296
  • - Research Article

Healthy Chilean Adolescents with HOMA-IR 2.6 Have Increased Cardiometabolic Risk: Association with Genetic, Biological, and Environmental Factors

R. Burrows | P. Correa-Burrows | ... | S. Gahagan
  • Special Issue
  • - Volume 2015
  • - Article ID 340838
  • - Review Article

Recent Trends in Therapeutic Approaches for Diabetes Management: A Comprehensive Update

Pragya Tiwari
  • Special Issue
  • - Volume 2015
  • - Article ID 807891
  • - Clinical Study

Effect of Rosiglitazone and Insulin Combination Therapy on Inflammation Parameters and Adipocytokine Levels in Patients with Type 1 DM

Metin Guclu | Ozen Oz Gul | ... | Canan Ersoy
Journal of Diabetes Research
 Journal metrics
Acceptance rate31%
Submission to final decision73 days
Acceptance to publication25 days
CiteScore3.020
Impact Factor3.040
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