Journal of Diabetes Research

Experimental Models of Type-2 Diabetic Nephropathy


Publishing date
15 Dec 2011
Status
Published
Submission deadline
15 Jun 2011

Lead Editor

1Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, Tokyo 113-8421, Japan

2ADVANCE Collaborative Group, George Institute for International Health, Sydney, NSW, Australia

3Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA

4Division of Nephrology, Department of Internal Medicine, Juntendo University School of Medicine, Tokyo 113-8421, Japan


Experimental Models of Type-2 Diabetic Nephropathy

Description

Type-2 diabetic nephropathy is one of the major long-term microvascular complications and is the major cause of morbidity and premature mortality in individuals with type-2 diabetes mellitus. The pathogenesis of diabetic nephropathy includes both metabolic and hemodynamic factors, as well as renal hypertrophy. Hyperglycemia is necessary, but not sufficient for its initiation and progression. Diabetic nephropathy is considered to result not only from alteration of chemical composition of the glomerular basement membrane and mesangium but also from an increase in extracellular matrix accumulation due to TGF-β activation. Although large numbers of candidate genes have been analyzed, those related to initiation and progression are still obscure in patients with type-2 diabetic nephropathy. Experimental models offer the key to an understanding of this multifactorial disease.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the pathogenesis of type-2 diabetic nephropathy. We are particularly interested in articles describing the recent advances in molecular genetics, immunology, cell biology, and structural biology using experimental models. Potential topics include, but are not limited to:

  • Advances in molecular genetics of type-2 diabetic nephropathy
  • Role of inflammation or the autoimmune process in type-2 diabetic nephropathy
  • Recent advances in structural biology in extracellular matrix
  • Role of cellular dysfunction in mesangial cells and podocytes
  • New cellular and animal models to test and understand the pathogenesis of type-2 diabetic nephropathy
  • Current concepts in the treatment of type-2 diabetic nephropathy using small molecules, siRNA, stem cells, and viral or nonviral gene therapy strategies
  • Recent clinical progress, especially treatment

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jdr/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 218917
  • - Editorial

Experimental Models of Type-2 Diabetic Nephropathy

Yasuhiko Tomino | Mark E. Cooper | ... | Yoshio Shimizu
  • Special Issue
  • - Volume 2012
  • - Article ID 749812
  • - Review Article

Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes

Meenalakshmi M. Mariappan
  • Special Issue
  • - Volume 2012
  • - Article ID 616313
  • - Review Article

New Experimental Models of Diabetic Nephropathy in Mice Models of Type 2 Diabetes: Efforts to Replicate Human Nephropathy

María José Soler | Marta Riera | Daniel Batlle
  • Special Issue
  • - Volume 2012
  • - Article ID 159874
  • - Research Article

An Angiotensin II Type 1 Receptor Blocker Prevents Renal Injury via Inhibition of the Notch Pathway in Ins2 Akita Diabetic Mice

Masaya Koshizaka | Minoru Takemoto | ... | Koutaro Yokote
  • Special Issue
  • - Volume 2011
  • - Article ID 278963
  • - Research Article

Osmolarity and Glucose Differentially Regulate Aldose Reductase Activity in Cultured Mouse Podocytes

Barbara Lewko | Elżbieta Latawiec | ... | Apolonia Rybczyńska
  • Special Issue
  • - Volume 2011
  • - Article ID 486305
  • - Review Article

Role of Mindin in Diabetic Nephropathy

Maki Murakoshi | Tomohito Gohda | ... | Yasuhiko Tomino
  • Special Issue
  • - Volume 2011
  • - Article ID 162092
  • - Research Article

Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)

Cristina Mega | Edite Teixeira de Lemos | ... | Flávio Reis
  • Special Issue
  • - Volume 2011
  • - Article ID 565647
  • - Research Article

Involvement of F-Actin in Chaperonin-Containing t-Complex 1 Beta Regulating Mouse Mesangial Cell Functions in a Glucose-Induction Cell Model

Jin-Shuen Chen | Li-Chien Chang | ... | Yuh-Feng Lin
  • Special Issue
  • - Volume 2011
  • - Article ID 514738
  • - Review Article

Role of T Cells in Type 2 Diabetic Nephropathy

Chia-Chao Wu | Huey-Kang Sytwu | ... | Yuh-Feng Lin
  • Special Issue
  • - Volume 2011
  • - Article ID 979354
  • - Research Article

Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy

Shinya Nakatani | Anna Kakehashi | ... | Hideki Wanibuchi
Journal of Diabetes Research
 Journal metrics
Acceptance rate31%
Submission to final decision73 days
Acceptance to publication25 days
CiteScore3.020
Impact Factor3.040
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