Journal of Diabetes Research

Role of Tissue and Systemic Hypoxia in Obesity and Type 2 Diabetes


Publishing date
22 Jul 2016
Status
Published
Submission deadline
04 Mar 2016

Lead Editor

1Virginia Commonwealth University, Richmond, USA

2University of Sydney, Sydney, Australia

3Harvard University, Boston, USA


Role of Tissue and Systemic Hypoxia in Obesity and Type 2 Diabetes

Description

Human lifestyle in most modern and developing societies has dramatically changed over past decades. Physical inactivity along with unrestricted access to calorie-dense foods has established an “obesogenic” environment and contributed to a serious epidemic of obesity and Type 2 diabetes (T2D), associated with increased morbidity and mortality. A new concept was recently proposed suggesting a central role played by adipose tissue hypoxia in promoting chronic inflammation, adiponectin reduction, adipocyte dysfunction, and death in obese individuals (Ye, 2009). Furthermore, systemic nocturnal intermittent hypoxia was shown to be associated with increased risk of developing T2D in middle-aged men (Muraki et al., 2010). However, it remains elusive how systemic versus local tissue oxygen tension affects the key pathophysiological processes of obesity and T2D, such as metabolic imbalance, inflammation, dysglycemia, and insulin resistance.

Accordingly this special issue is designed to invite and showcase the cutting-edge original research articles and reviews focusing on the impact of continuous or intermittent systemic hypoxia (e.g., altitude sojourn/training, obstructive sleep apnea, and hypoxic conditioning), as well as localized tissue hypoxia (in adipose and other types of tissues), on the pathogenesis, progression, and possible novel treatments of obesity and T2D. New revelation of brown adipose tissue (BAT) activity in adult humans has stimulated vigorous investigations on how it can serve as a prevention and treatment target for obesity and insulin resistance. Thus, a particular emphasis is to analyze the role of BAT in whole-body energy homeostasis and substrate metabolism under normal and hypoxic conditions. Our primary goal is to provide a platform for insightful discussions and exchanges of divergent ideas concerning systemic and local hypoxia as trigger or treatment (in some cases) of adipose tissue dysfunction and other organ injuries in obesity and T2D.

Potential topics include, but are not limited to:

  • Role of hypoxia signaling in pathogenesis and progression of obesity and T2D
  • Crosstalks between hypoxia and inflammation at systemic and tissue levels in obesity and T2D
  • Effects of systemic or local hypoxia on white and brown adipose tissue structure, function, removal, and regeneration
  • Modulatory role of BAT in whole-body energy balance and glucose homeostasis under normoxia and hypoxia
  • Effects of systemic or local hypoxia on pancreatic beta cell function and survival as well as kidney function in obesity and T2D
  • Interactions between obstructive sleep apnea and obesity or insulin resistance
  • Therapeutic potential of intermittent hypoxic conditioning/training for prevention and treatment of obesity and T2D
  • Effects of altitude sojourn or training on obesity and T2D
  • Organ/tissue ischemia-reperfusion injury in obese and T2D

Articles

  • Special Issue
  • - Volume 2016
  • - Article ID 1527852
  • - Editorial

Role of Tissue and Systemic Hypoxia in Obesity and Type 2 Diabetes

Lei Xi | Chin-Moi Chow | Xingxing Kong
  • Special Issue
  • - Volume 2016
  • - Article ID 2481659
  • - Review Article

The Role of Hyperglycemia and Insulin Resistance in the Development and Progression of Pulmonary Arterial Hypertension

Daniel Grinnan | Grant Farr | ... | Lori Sweeney
  • Special Issue
  • - Volume 2016
  • - Article ID 2961954
  • - Research Article

Metformin Protects H9C2 Cardiomyocytes from High-Glucose and Hypoxia/Reoxygenation Injury via Inhibition of Reactive Oxygen Species Generation and Inflammatory Responses: Role of AMPK and JNK

Mingyan Hu | Ping Ye | ... | Feiyan Yang
  • Special Issue
  • - Volume 2016
  • - Article ID 6934937
  • - Review Article

A Molecular and Whole Body Insight of the Mechanisms Surrounding Glucose Disposal and Insulin Resistance with Hypoxic Treatment in Skeletal Muscle

R. W. A. Mackenzie | P. Watt
  • Special Issue
  • - Volume 2016
  • - Article ID 1324347
  • - Review Article

Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy

Lei Pang | Yin Cai | ... | Zhengyuan Xia
  • Special Issue
  • - Volume 2016
  • - Article ID 6785948
  • - Research Article

Impaired Thermogenesis and a Molecular Signature for Brown Adipose Tissue in Id2 Null Mice

Peng Zhou | Maricela Robles-Murguia | ... | Giles E. Duffield
  • Special Issue
  • - Volume 2016
  • - Article ID 7481470
  • - Research Article

Hypoxia Alters the Expression of Dipeptidyl Peptidase 4 and Induces Developmental Remodeling of Human Preadipocytes

Helena H. Chowdhury | Jelena Velebit | ... | Robert Zorec
  • Special Issue
  • - Volume 2016
  • - Article ID 1587594
  • - Research Article

Free Fatty Acids Activate Renin-Angiotensin System in 3T3-L1 Adipocytes through Nuclear Factor-kappa B Pathway

Jia Sun | Jinhua Luo | ... | Hong Chen
Journal of Diabetes Research
 Journal metrics
Acceptance rate34%
Submission to final decision85 days
Acceptance to publication27 days
CiteScore3.020
Impact Factor3.040
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