Journal of Diabetes Research

Osteoporosis and Fragility Fractures in Type 2 Diabetes

Publishing date
01 Jun 2020
Submission deadline
07 Feb 2020

1University of Messina, Messina, Italy

2University of Milan, Milan, Italy

3University of Catania, Catania, Italy

4University of Siena, Siena, Italy

Osteoporosis and Fragility Fractures in Type 2 Diabetes


In the last decades, the global rise of obesity and sedentary lifestyles, together with an aging population, lead to increased incidence and prevalence of type 2 diabetes (T2DM). T2DM is a major cause of disability, socioeconomic costs, and increased risk of all-cause mortality, although screening programmes and the availability of effective therapies prevent or delay complications.

Fragility fractures are increasingly recognized as an important complication of T2DM and are associated with excess morbidity, mortality, and health care costs. Bone mineral density (BMD) in T2DM is often normal or even slightly elevated compared with an age-matched control population. Thus, the standard diagnostic tool for osteoporosis based on DXA derived BMD seems not enough for the identification of T2DM patients at risk for fracture. Osteoporosis is often an underdiagnosed T2DM related complication. Moreover, the complex pathophysiology that contributes to bone damage in T2DM remains still largely unknown.

This Special Ossue aims to update the clinical approach to fracture risk in subjects with T2DM and to move the field forward, suggesting how to decrease the fracture rate in the clinical scenario. We welcome both original research and review articles.

Potential topics include but are not limited to the following:

  • Update on the epidemiology of fractures in T2DM
  • Clinical and instrumental diagnostic tools of bone fragility in T2DM
  • Pathogenesis of bone fragility in T2DM
  • Biomarkers predictive of bone fragility in T2DM
  • Prevention of fractures in T2DM
  • The role of antidiabetic drugs on bone health and fracture rate
  • The effects of antiosteoporotic drugs on T2DM patients


  • Special Issue
  • - Volume 2020
  • - Article ID 9342696
  • - Editorial

Osteoporosis and Fragility Fractures in Type 2 Diabetes

Iacopo Chiodini | Antonino Catalano | ... | Agostino Gaudio
  • Special Issue
  • - Volume 2020
  • - Article ID 3982831
  • - Research Article

Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study

Xin Zhao | Xiaofeng Yu | Xiaomei Zhang
  • Special Issue
  • - Volume 2020
  • - Article ID 7608964
  • - Review Article

Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility

C. Eller-Vainicher | E. Cairoli | ... | L. Gennari
  • Special Issue
  • - Volume 2020
  • - Article ID 1508258
  • - Research Article

Assessment of Risk Factors for Fractures in Patients with Type 2 Diabetes over 60 Years Old: A Cross-Sectional Study from Northeast China

Yan Guo | Yingfang Wang | ... | Difei Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 6757428
  • - Research Article

FOXO1 Mediates Advanced Glycation End Products Induced Mouse Osteocyte-Like MLO-Y4 Cell Apoptosis and Dysfunctions

Citong Zhang | Wei Wei | ... | Yanmin Zhou
  • Special Issue
  • - Volume 2019
  • - Article ID 3876957
  • - Research Article

Type 2 Diabetes Mellitus Increases the Risk to Hip Fracture in Postmenopausal Osteoporosis by Deteriorating the Trabecular Bone Microarchitecture and Bone Mass

Sahar Mohsin | Suneesh Kaimala | ... | Eric Mensah Brown
Journal of Diabetes Research
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