Journal of Diabetes Research

New Insights into Diabetic Kidney Disease: The Potential Pathogenesis and Therapeutic Targets


Status
Published

Lead Editor

1Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China

2Rush University, Chicago, USA

3Chonbuk National University, Jeonju, Republic of Korea

4First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

5Yale University, New Haven, USA


New Insights into Diabetic Kidney Disease: The Potential Pathogenesis and Therapeutic Targets

Description

Diabetic kidney disease (DKD), the leading cause of chronic kidney disease (CKD) and end stage renal disease (ESRD), has garnered much attention because of its high prevalence, poor prognosis, and heavy economic burden. The multifactorial intervention, including lowering blood pressure and glucose levels, inhibiting the renin-angiotensin system, and controlling lipids, fails to fully prevent the onset and progression of DKD. Therefore, more specific pathophysiologic mechanisms or renal cellular processes underlying DKD should be identified to develop additional treatment modalities and strategies. Also, some predictive biomarkers should be further studied for moving towards clinical application, as well as more randomized controlled trials should be carried out to summarize valuable clinical data.

Fortunately, in the last years the pathogenesis of DKD has been intensely investigated and a better understanding of the molecular and cellular processes in DKD, such as accelerated senescence in renal intrinsic cells, autophagy inactivation, and lysosomal dysfunction, has been provided. Accordingly, some targets have led to a development of new therapeutic strategies. Furthermore, quite a few biomarkers, such as microRNAs, KIM-1, and NGAL, offer us a potential perspective for diagnosis, management, and prognosis of DKD. In addition to the results from ACCORD, ADVANCE, and VADT trials, some useful data are also obtained from a few randomized controlled trials.

In view of this, we invite investigators to contribute original research articles as well as review articles that focus on the potential pathogenesis and therapeutic targets of DKD discovered in recent years.

Potential topics include but are not limited to the following:

  • What is new for the potential pathogenesis
  • Novel therapeutic targets in experimental study
  • Recent clinical advances in diagnostic, prognostic, and predictive biomarkers
  • New insights and developments in clinical trials

Articles

  • Special Issue
  • - Volume 2017
  • - Article ID 3945469
  • - Editorial

New Insights into Diabetic Kidney Disease: The Potential Pathogenesis and Therapeutic Targets

Wei Jing Liu | Jochen Reiser | ... | Shuta Ishibe
  • Special Issue
  • - Volume 2017
  • - Article ID 4989847
  • - Research Article

Sulodexide Protects Renal Tubular Epithelial Cells from Oxidative Stress-Induced Injury via Upregulating Klotho Expression at an Early Stage of Diabetic Kidney Disease

Yu Ning Liu | Jingwei Zhou | ... | Wei Jing Liu
  • Special Issue
  • - Volume 2017
  • - Article ID 2615286
  • - Review Article

Research Progress on Mechanism of Podocyte Depletion in Diabetic Nephropathy

Haoran Dai | Qingquan Liu | Baoli Liu
  • Special Issue
  • - Volume 2017
  • - Article ID 4319057
  • - Research Article

Renoprotective Effect of the Shen-Yan-Fang-Shuai Formula by Inhibiting TNF-α/NF-κB Signaling Pathway in Diabetic Rats

Jie Lv | Zhen Wang | ... | Yaoxian Wang
  • Special Issue
  • - Volume 2017
  • - Article ID 7242384
  • - Review Article

Role of Epigenetic Histone Modifications in Diabetic Kidney Disease Involving Renal Fibrosis

Jing Sun | Yangwei Wang | ... | Lining Miao
  • Special Issue
  • - Volume 2017
  • - Article ID 3232848
  • - Review Article

Soluble Urokinase Receptor and the Kidney Response in Diabetes Mellitus

Ranadheer R. Dande | Vasil Peev | ... | Jochen Reiser
  • Special Issue
  • - Volume 2017
  • - Article ID 3797802
  • - Review Article

Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy

Wenpeng Cui | Xu Min | ... | Ping Luo
  • Special Issue
  • - Volume 2017
  • - Article ID 6483572
  • - Research Article

PGC1α Activators Mitigate Diabetic Tubulopathy by Improving Mitochondrial Dynamics and Quality Control

So-Young Lee | Jun Mo Kang | ... | Sang Ho Lee
  • Special Issue
  • - Volume 2017
  • - Article ID 5728087
  • - Research Article

Glycopatterns of Urinary Protein as New Potential Diagnosis Indicators for Diabetic Nephropathy

Hanyu Zhu | Moyan Liu | ... | Dong Zhang
  • Special Issue
  • - Volume 2017
  • - Article ID 8391253
  • - Research Article

Transcriptional Profile of Kidney from Type 2 Diabetic db/db Mice

Haojun Zhang | Tingting Zhao | ... | Ping Li
Journal of Diabetes Research
 Journal metrics
Acceptance rate32%
Submission to final decision68 days
Acceptance to publication26 days
CiteScore5.500
Impact Factor2.965
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