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Journal of Electrical and Computer Engineering
Volume 2011, Article ID 427196, 17 pages
http://dx.doi.org/10.1155/2011/427196
Research Article

Development of AIDA v4.3b Diabetes Simulator: Technical Upgrade to Support Incorporation of Lispro, Aspart, and Glargine Insulin Analogues

1Department of Imaging (MRU), Imperial College of Science, Technology and Medicine (NHLI), Royal Brompton Hospital, London SW3 6NP, UK
2Department of Radiology, Barts and The London NHS Trust, Royal London Hospital, Whitechapel, London E1 1BB, UK
3Institute for Systems Dynamics, University of Stuttgart, 70569 Stuttgart, Germany
4Instituto Universitario de Automática e Informática Industrial, Universidad Politécnica de Valencia, 46022 Valencia, Spain
5Campus Vaihingen, University of Stuttgart, 70569 Stuttgart, Germany
6Department of Informatics and Medical Technology, Faculty of Health Sciences, Semmelweis University, Budapest 1088, Hungary

Received 9 September 2010; Accepted 14 November 2010

Academic Editor: Patrizio Tatti

Copyright © 2011 Eldon D. Lehmann et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. AIDA is an interactive educational diabetes simulator available on the Internet without charge since 1996 (accessible at: http://www.2aida.org/). Since the program’s original release, users have developed new requirements, with new operating systems coming into use and more complex insulin management regimens being adopted. The current work has aimed to design a comprehensive diabetes simulation system from both a clinical and information technology perspective. Methods. A collaborative development is taking place with a new generic model of subcutaneous insulin absorption, permitting the simulation of rapidly-acting and very long-acting insulin analogues, as well as insulin injections larger than 40 units. This novel, physiological insulin absorption model has been incorporated into AIDA v4. Technical work has also been undertaken to install and operate the AIDA software within a DOSBox emulator, to ensure compatibility with Windows XP, Vista and 7 operating systems as well as Apple Macintosh computers running Parallels PC emulation software. Results. Plasma insulin simulations are demonstrated following subcutaneous injections of a rapidly-acting insulin analogue, a short-acting insulin preparation, intermediate-acting insulin, and a very long-acting insulin analogue for injected insulin doses up to 60 units of insulin. Discussion. The current work extends the useful life of the existing AIDA v4 program.