Development of AIDA v4.3b Diabetes Simulator: Technical Upgrade to Support Incorporation of Lispro, Aspart, and Glargine Insulin Analogues

Figure 5

A bench test study concerning spatial discretization reveals that a fixed number of shells is not appropriate for any insulin class, dosage, or preparation. Accurate simulation results depend on the insulin preparation and the dose. The number of shells required for an insulin absorption profile computation with an area under the curve (AUC) error below 1% is shown. The time step considered for 2 IU of rapidly acting insulin was reduced to 0.002 to avoid numerical instabilities. The value for 1 IU could not be computed due to memory resources limitations (number of shells greater than 250 are estimated).