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Journal of Electrical and Computer Engineering
Volume 2011 (2011), Article ID 953064, 12 pages
Research Article

Regression Methods for Ophthalmic Glucose Sensing Using Metamaterials

1Institute for System Dynamics, University of Stuttgart, Pfaffenwaldring 9, 70569 Stuttgart, Germany
24th Physics Institute, University of Stuttgart, Pfaffenwaldring 57, 70569 Stuttgart, Germany

Received 31 May 2011; Accepted 5 August 2011

Academic Editor: David Hamilton

Copyright © 2011 Philipp Rapp et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present a novel concept for in vivo sensing of glucose using metamaterials in combination with automatic learning systems. In detail, we use the plasmonic analogue of electromagnetically induced transparency (EIT) as sensor and evaluate the acquired data with support vector machines. The metamaterial can be integrated into a contact lens. This sensor changes its optical properties such as reflectivity upon the ambient glucose concentration, which allows for in situ measurements in the eye. We demonstrate that estimation errors below 2% at physiological concentrations are possible using simulations of the optical properties of the metamaterial in combination with an appropriate electrical circuitry and signal processing scheme. In the future, functionalization of our sensor with hydrogel will allow for a glucose-specific detection which is insensitive to other tear liquid substances providing both excellent selectivity and sensitivity.