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Journal of Environmental and Public Health
Volume 2012, Article ID 101850, 10 pages
Clinical Study

Evaluation of a Bladder Cancer Cluster in a Population of Criminal Investigators with the Bureau of Alcohol, Tobacco, Firearms and Explosives—Part 1: The Cancer Incidence

1Federal Occupational Health, Department of Health and Human Services, 4550 Montgomery Avenue, Suite 950, Bethesda, MD 20814, USA
2Division of Occupational and Environmental Medicine, Department of Medicine, Johns Hopkins University School of Medicine, 615 N. Wolfe Street, Baltimore, MD 21205, USA

Received 24 August 2012; Accepted 22 October 2012

Academic Editor: Edward Trapido

Copyright © 2012 Susan R. Davis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study investigated a bladder cancer cluster in a cohort of employees, predominately criminal investigators, participating in a medical surveillance program with the United States Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) between 1995 and 2007. Standardized incidence ratios (SIRs) were used to compare cancer incidences in the ATF population and the US reference population. Seven cases of bladder cancer (five cases verified by pathology report at time of analysis) were identified among a total employee population of 3,768 individuals. All cases were white males and criminal investigators. Six of seven cases were in the 30 to 49 age range at the time of diagnosis. The SIRs for white male criminal investigators undergoing examinations were 7.63 (95% confidence interval = 3.70–15.75) for reported cases and 5.45 (2.33–12.76) for verified cases. White male criminal investigators in the ATF population are at statistically significant increased risk for bladder cancer.