Table 5: Comparison of outcomes between patients who commenced the COMB protocol for declined drug therapy and those who previously showed no improvement on bisphosphonates.

Percent change Patients who declined therapy with bisphosphonate ( 𝑁 = 4 8 )Patients who reported failure with previous bisphosphonate therapy ( 𝑁 = 2 9 )

Femoral neck3%5%
Total hip3%3%
Lowest hip site4%5%
Total spine6%6%
Lowest spine site9%8%