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Journal of Environmental and Public Health
Volume 2013 (2013), Article ID 351528, 9 pages
Research Article

A Qualitative Survey of Five Antibiotics in a Water Treatment Plant in Central Plateau of Iran

1Environment Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
2Department of Chemistry, Faculty of Sciences, Islamic Azad University, Kerman Branch, Kerman, Iran
3Pharmaceutics Research Center, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

Received 11 November 2012; Revised 16 December 2012; Accepted 1 February 2013

Academic Editor: Ajay K. Gupta

Copyright © 2013 Mohsen Heidari et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. This study aimed to survey a total of five common human and veterinary antibiotics based on SPE-LC-MS-MS technology in a water treatment plant at central plateau of Iran. Also two sampling techniques, passive and grab samplings, were compared in the detection of selected antibiotics. Materials and Methods. In January to March 2012, grab and passive samples were taken from the influent and effluent of a water treatment plant. The samples were prepared using solid-phase extraction (SPE), and extracts were analyzed by liquid chromatography tandem mass spectrometry (LC-MS-MS). Results. The results showed that enrofloxacin, oxytetracycline, and tylosin were not detected in none of the samples. However, ampicillin was detected in the grab and passive samples taken from the influent (source water) of the plant, and ciprofloxacin was detected in passive samples taken from the influent and effluent (finished water) of the plant. Conclusion. The results imply that passive sampling is a better approach than grab sampling for the investigation of antibiotics in aquatic environments. The presence of ampicillin and ciprofloxacin in source water and finished water of the water treatment plant may lead to potential emergence of resistant bacteria that should be considered in future studies.