Selected Liver Markers in Predicting the Severity of Organophosphate and Carbamate Poisoning
Table 2
Comparison of RBC cholinesterase, liver transaminases, and bilirubin and severity on admission and at discharge among the POP groups.
Biochemical test
Mild POP median (IQR)
Moderate POP median (IQR)
Severe POP median (IQR)
X2 ( value)
On admission^ (n = 166)
87
68
11
RBC cholinesterase (U/g Hgb)
22.4 (9.9–25.6)
3.0 (1.0–12.0)
0.7 (0.3–2.1)
47.41 (≤0.001)
ALT (IU/L)
17.8 (11.9–23.2)
22.3 (15.3–39.2)
22.7 (17.3–54.7)
14.32 (≤0.001)
AST (IU/L)
33.9 (25.8–43.3)
47.4 (35.0–65.8)
73.2 (26.1–121.5)
26.48 (≤0.001)
AST/ALT
1.92 (1.49–2.70)
2.15 (1.59–2.83)
2.25 (1.06–3.37)
0.846 (0.655)
Direct bilirubin (mg/dL)
0.12 (0.10–0.18)
0.13 (0.10–0.19)
0.14 (0.80–0.24)
0.23 (0.89)
Total bilirubin (mg/dL)
0.53 (0.37–0.81)
0.56 (0.34–0.92)
0.51 (0.42–0.69)
0.52 (0.78)
Hospital stay (days)
3 (3–4)
5 (4–7)
8 (6–10)
49.51 (≤0.001)
No. of patients being ventilated (%)
2 (2.3)
34 (50.0)
11 (100.0)
72.18 (≤0.001)
No. of deaths (%)
2 (2.3)
5 (7.3)
2 (18.2)
5.60 (0.06)
Seriously ill patients (%)
03 (3.5)
34 (50.0)
11 (100.0)
RBC cholinesterase (U/g Hgb)
9.4 (6.5–15.8)
2.0 (0.7–7.8)
0.8 (0.5–2.5)
4.18 (0.12)
ALT (IU/L)
17.6 (13.0–19.9)
25.7 (15.8–48.5)
30.7 (19.7–48.9)
2.50 (0.29)
AST (IU/L)
54.9 (45.2–71.9)
50.0 (35.0–87.1)
73.2 (46.2–121.5)
1.21 (0.55)
AST/ALT
4.21 (3.34–4.63)
2.08 (1.53–2.84)
2.25 (1.60–3.37)
4.14 (0.13)
Direct bilirubin (mg/dL)
0.25 (0.23–0.25)
0.14 (0.11–0.20)
0.14 (0.80–0.21)
3.44 (0.18)
Total bilirubin (mg/dL)
0.73 (0.68–0.74)
0.53 (0.35–0.87)
0.51 (0.42–0.61)
1.40 (0.50)
At discharge# (n = 157)
85
63
09
ALT (IU/L)
17.0 (13.4–26.7)
23.5 (14.2–32.7)
23.0 (20.7–38.4)
5.74 (0.06)
AST (IU/L)
30.0 (25.4–42.3)
37.9 (29.9–56.8)
40.1 (31.0–80.3)
11.35 (≤0.001)
Direct bilirubin (mg/dL)
0.14 (0.10–0.19)
0.14 (0.10–0.19)
0.10 (0.08–0.16)
3.10 (0.21)
Total bilirubin (mg/dL)
0.59 (0.40–0.90)
0.56 (0.38–0.78)
0.38 (0.31–0.53)
4.29 (0.12)
IQR = interquartile range; X2: chi-square; significant at 0.01 level; ^ included dead and seriously ill patients.Seriously ill patients were shown separately but included in the on-admission category, #Seriously ill patients but not dead.
