Research Article
Green Coffee Bean Extract Potentially Ameliorates Liver Injury due to HFD/STZ-Induced Diabetes in Rats
Figure 7
Histopathological changes of hepatic tissue following GCBE (50 and 100 mg kg−1) or metformin (200 mg kg−1) in high-fat diet-streptozotocin-induced diabetes in male rats stained with H&E. (a-b) Normal liver structure characterized by the normal portal veins and central veins were observed in the control and green coffee water extract-treated alone groups, respectively. (c) Focal infiltration of inflammatory cells and aggregation in between the damaged cells were observed in the HFD and STZ groups. (d-f) Metformin or green coffee showed improvement in the pathological changes in the liver of rats evidenced by the normal structure of the liver.
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