Protective Effects of Aqueous Extracts of the Herb of Paederia scandens (Lour.) Merr. against HCl/EtOH-Induced Gastric Ulcer in Rats: Involvement and Inhibitors’ Identification of NF-κB Signaling

Table 1

Chemical constituents identified in PS-AE by using UPLC-MS².

Peak no.	Analyst	Rt (min)	Molecular formula	Calc. MW	Error (ppm)	MS^1 (m/z)	MS^2 (m/z)
1	Asperulosidic	4.07	C18H24O12	432.1270	0.52	431.016 [M − H]^−	269.0650, 251.0565, 225.0770, 207.0668, and 183.0668
2	Paederosidic acid^S	5.89	C18H24O12S	464.0983	1.12	463.0909 [M − H]^−	428.2374, 371.0979, 283.0290, 264.0499, 209.0457, 191.0350, 165.0558, 47.0453, and 123.0458
3	Benzoic acid	5.93	C7H6O2	122.0369	0.69	121.0297 [M − H]^−	115.9207, 109.9421, 91.9315, and 77.0045
4	Rutin^S	6.58	C27H30O16	610.1528	3.12	609.1469 [M − H]^−	365.9859, 343.0457, 300.0279, 273.0397, and 151.0633
5	Lariciresinol-4-O-glucoside	6.71	C26H34O11	522.2107	1.14	521.2059 [M − H]^−	476.6039, 359.1505, 307.8777, and 89.0249
6	5,7-Dihydroxy-2-methylbenzopyran-4-one	6.78	C10H8O4	192.0416	−3.44	193.0489 [M + H]^+	178.0251, 149.0226. 139.0382, 133.0272, 121.0280, and 103.0172
7	Scopoletin	6.88	C10H8O4	192.0416	−3.44	193.0483 [M + H]^+	175.0476, 165.0273, and 147.0166
8	Coumarone	7.52	C8H6O	118.0414	−3.69	119.0488 [M + H]^+	105.0445, 92.0572, 91.0540, and 79.0540
9	Quercetin^S	9.20	C15H10O7	302.0421	−3.06	303.049 [M + H]^+	285.0390, 257.0443, 229.0476, and 165.0188
10	Astragalin	9.23	C21H20O11	448.1011	3.76	447.0936 [M−H]^−	300.0278, 283.0248, 255.0310, and 151.0043
11	Paederoside^S	9.55	C18H22O11S	446.0877	4.12	447.0937 [M + H]^+	300.0278, 283.0224, 271.0248, 255.0291, 151.0042, and 121.0293
12	Ustilaginoidin A	9.72	C28H18O10	514.0916	3.17	513.0844 [M−H]^−	361.2084
13	Diatretyne 3	9.74	C10H6O3	174.0312	−3.07	175.0384 [M + H]^+	147.0437, 131.0482, 119.0488, 116.0702, and 91.0540
14	(3S,5S,6S)-Communiol C	10.44	C9H16O4	188.1049	0.15	189.0542 [M + H]^+	161.0608 and 129.0336
15	Halstoctacosanolide C	12.27	C48H78O10	814.5578	−2.04	815.5667 [M + H]^+	637.9799, 567.1544, 365.2295, and 147.0263
16	Linarin^S	22.42	C28H32O14	592.1786	−2.16	593.1852 [M + H]^+	285.0748 and 85.0280
17	Apigenin 5-(6″-malonylglucoside)	23.68	C24H22O13	518.1058	−0.43	517.0994 [M − H]^−	401.0883, 383.0761, 357.0623, 313.0720, and 225.0555
18	Kaempferol^S	23.77	C15H10O6	286.0472	−0.55	287.0539 [M + H]^+	287.0548, 258.0511, 183.0288, 165.0183, 153.0189, 133.0292, and 121.0281
19	Isoliquiritigenin	23.89	C15H12O4	256.0727	−3.2	257.0801 [M + H]^+	162.0707, 147.0437, 137.0233, and 121.0276
20	Apigenin 7-(2″-acetyl-6″-methylglucuronide)	23.89	C24H22O12	502.1107	−0.88	501.1043 [M − H]^−	399.1078, 255.0666, 193.0475, and 153.0205
21	Daphyloside	23.90	C19H26O12	446.4025	4.1	445.1147 [M − H]^−	445.1147, 401.0883, 357.0987, 313.0714, 281.0048, 255.0665, 225.0559, 181.0658, and 135.0090
22	Radicinin	24.00	C12H12O5	236.0678	−3.06	237.0749 [M + H]^+	204.1709, 193.0490, and 149.0229
23	Daidzein	24.10	C21H20O9	416.1113	2.51	415.1034 [M − H]^−	357.0621, 313.0921, 291.0044, 271.0013, 225.0559, 181.0661, and 121.0296
24	Nobiletin	24.63	C21H22O8	402.1305	−2.38	401.0900 [M − H]^−	357.0635, 313.0721, 225.0563, 181.0658, and 121.0296

Note: S means having been verified by standards.