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| Mushroom species and their extracts | Types of skin diseases and/or disorders | Effect | Results | References |
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| Mannogalactan from Pleurotus eryngii (cold aqueous extraction) | Melanoma (skin cancer) | Anticancer | 60% reduction of the tumor volume in melanoma-bearing C57BL/6 mice with the treatment of mannogalactan (50 mg/kg) compared to the control group | [108] |
| Choloroform extract of Cordyceps taii (methanol extraction) | Considerable in vivo potential of antitumor and antimetastatic activities probably due to its antiproliferation, antioxidant, and immunoregulatory effects | [93] |
| Extract of bioactive compounds from Pleurotus ferulae (ethanol extraction) | ↓tumor formation, ↓growth, size, and final weight of tumor in vivo with prevention of tumor cell proliferation | [109] |
| ↓cell migration, ↑apoptosis |
| CARI III (dietary supplement) is composed of Phellinus linteus, Inonotus obliquus, Antrodia camphorata, and Ganoderma lucidum (CARI, Inc., Seoul, South Korea) | ↓tumor weight with the treatment of 300 mg CARI III/kg/day compared to the treatment of doxorubicin (Dox) | [110] |
| ↑life span (50.88%) in the CARI III-administered animal group comprising the tumor control animal group |
| Methanol extract including total terpenoids and purified methanol extract including mainly acidic terpenoids from Ganoderma lucidum (methanol extraction) | ↓tumor growth in vivo with the treatment of both extract types obtaining a more potent effect with methanol extract including total terpenoids than purified methanol extract including mainly acidic terpenoids | [94] |
| 14 times lower tumor volume in the group of B16-melanoma-bearing mice with the treatment of methanol extract, including total terpenoids, compared to control tumor-bearing mice |
| Extracts of Cordyceps sinensis (extraction with petroleum ether, ethyl acetate, ethanol and hot water) | Anticancer/Antitumor | ↓B16-induced melanoma in C57BL/6 mice and approximately 60% reduction of tumor size more than 27 days with ethyl acetate extraction | [111] |
| Acidic polysaccharide from Phellinus linteus | Antimetastatic | ↓melanoma cell metastasis in mice | [112] |
| ↓adhesion, ↓invasion of cancer cells through the extracellular matrix not directly influential on the growth of cancer cell |
|
| Hot water extract of Ganoderma lucidum | Skin wounds | Wound healing/Antioxidant | The highest wound closure in streptozotocin-induced diabetic rats with the treatment of 10% (w/w) aqueous extract cream compared to treated groups with Intrasite gel (positive control) and aqueous cream (negative control) | [113] |
| The shortest reepithelization period with the treatment of 10% (w/w) aqueous extract cream |
| Considerable higher in vivo antioxidant activity with 15% (w/w) aqueous extract compared to negative and positive control groups |
| Lower oxidative protein products and lipid damage in treated diabetic rats with aqueous extract compared to negative and positive control groups |
|
| Extract of Cantharellus cibarius | Skin wounds (circular excision and linear incision wound models) | Wound healing/Antiinflammatory | ↑healing activity for treated rats with extract of C. cibarius, and Madecassol (reference drug) compared to nontreated and vehicle-treated rats completely repairing the epidermal layer, increasing collagen production, considerable neovascularization and epithelization degree in the treated rats with the extract | [114] |
| ↓COX-2 in treated rats with extract than in nontreated and vehicle-treated rats |
|
| Extract of Antrodia camphorate (ethanol extraction) | Skin wounds (excision model) | Wound healing/Anti-inflammatory | ↑wound healing closure in treated rats with extract (for both doses of 100 mg/kg and 200 mg/kg) and Intrasite gel (reference drug) compared to treated rats with vehicle | [115] |
| Considerably less scar width at wound closure and less inflammatory cells, more collagen, and more fibroblast in granulation tissue with extract treatment than vehicle treatment |
|
| Aqueous lyophilized extract of Ganoderma lucidum | Skin wounds | Wound healing | ↑healing activity with an increase in wound contraction, accumulation of collagen, hexosamine, and total protein content for treated rats with extract | [80] |
| Sparassis crispa | ↑wound closure in streptozotocin-induced diabetic rats with oral administration of S. crispa | [116] |
| ↑migration of macrophage and fibroblast, ↑regeneration of collagen, and epithelialization with S. crispa treatment compared to the control group (nontreated with S. crispa) |
| Aqueous extract of Hericium erinaceus | Wound healing | Higher and quick wound healing in rats treated with the extract and Intrasite gel than in rats treated with sterilized distilled water | [117] |
| Considerably less scar width in healed wound area and lower macrophages and higher collagen in the healed wound for treated rats with extract than treated rats with sterilized distilled water |
|
| Extract of Hypsizigus marmoreus (ethanol extraction) | Atopic dermatitis | Antiatopic dermatitis/Antiinflammatory | ↓severity score of dermatitis and the epidermis thickness in treated BALB/c mice group with extract for five weeks compared to another treated group with PCL | [95] |
| ↓IL-1β, ↓IFN-γ production levels in concanavalin A-stimulated and lipopolysaccharide-stimulated mouse splenocytes and macrophages with extract treatment |
| ↑IL-4 with administration of extract to splenocytes of mouse |
| Aqueous extract of Cordyceps militaris | Antiatopic dermatitis/Antiinflammatory | ↓epidermal and dermal thickness and infiltration of mast cell in ears of DFE/DNCB-induced BALB/c mice group with oral administration of the extract | [118] |
| ↓immunoglobulin levels and gene expression of T helper (Th)1/Th2 cytokines in the tissue of mouse ear with extract |
| Extract of Lyophyllum decastes | Antiatopic dermatitis/Antiallergic | ↓AD-like skin lesions development according to low scores of total skin severity and levels of immunoglobulin E in NC/Nga mice with oral administration of the extract | [119] |
| ↓IL-4, no inhibition of IFN-γ production with extract treatment |
| Exertion of antiallergic action due to suppression of serum IgE and Th2-type immune responses with extract treatment |
| Aqueous extract of Grifola frondosa | Antiatopic dermatitis/Anti-inflammatory | ↓score of dorsal skin dermatitis with extract treatment | [89] |
| ↓AD-like skin lesion, ↓Th-1/Th-2 response in NC/Nga mice with extract treatment |
| Synergistic effect in AD-like skin lesions by reduction of serum IgE, mast cells infiltration, and cytokines expression with combined treatment of extract and dexamethanose |
|
| Extracts of Pleurotus eryngii | | Antiatopic dermatitis/Antiinflammatory/Antiallergic | ↓AD-like skin lesions in DNCB-induced NC/Nga mice with continuous extract treatment | [120] |
| ↓severity of dermatitis, ↓IgE and thymus and activation-regulated chemokine (TARC), and mRNA expression of TNF-α, INF-γ, IL-4, IL-5, and IL-13 in mice with extract treatment |
| ↓dermis and dermal infiltration thickness of inflammatory cells and mast cells with extract treatment |
| ↓allergic contact dermatitis due to modulation of T helper Th1 and Th2 responses and decrease of the inflammatory cells and mast cells infiltration in the skin lesions in NC/Nga mice |
|
| Extract of Ganoderm A formosanum (ethanol extraction) | Abnormality of skin pigmentation | Antityrosinase/Antimelanogenesis | ↓surface pigmentation level on the body of zebrafish with extract treatment after 48 h due to considerable reduction of tyrosinase activity and melanin content | [121] |
| No significant differentiation in terms of morphology and mortality of treated zebrafish with extract compared to the control group |
| Less toxicity and similar efficiency for depigmentation with extract treatment in lower dosages than kojic acid treatment |
| Extract of Antrodia cinnamomea (ethanol extraction) | Antityrosinase/Antimelanogenesis | ↓hyperpigmentation, ↓tyrosinase activity | [122] |
| ↓melanin formation activity for treated zebrafish with extract |
| Less toxic effect and similarly effective depigmentation of zebrafish with extract treatment at a lower dosage (50 ppm) compared to kojic acid (1400 ppm) |
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