Aqueous Extract of Sparganii Rhizoma and Curcumae Rhizoma Induces Apoptosis and Inhibits Migration in Human Oral Squamous Cell Carcinoma

Figure 6

SRCR inhibited migration of OSCC cells by modulating expression of MMPs. (a-b) After incubating OSCC cells (HSC3 and SCC4) with a control solution or various concentrations of SRCR for 24 h, cell movement and migration were measured in vitro using a wound-healing assay and transwells; (c–f) after incubating OSCC cells (HSC3 and SCC4) with a control solution or various concentrations of SRCR for 24 h, the expression of MMP2, MMP9, MMP12, and MMP13 mRNA and protein was, respectively, examined via qPCR and western blot analysis. Data are expressed as mean ± SD. compared to the control group.

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