Ursolic Acid Inhibits the Growth of Gastric Cancer by Targeting KLF4/YAP1

Figure 2

UA inhibited the growth of GC BGC-823 cells through upregulation of KLF4. (a) Changes of KLF4 mRNA levels in BGC-823 cells after treatment with UA. (b) Changes of KLF4 protein levels in BGC-823 cells after treatment with UA. (c) Changes of CTGF, P21, and P27 mRNA levels in BGC-823 cells after treatment with UA. (d) Real-time PCR and western blot analyses of KLF4 expression levels after transfection of the KLF4 overexpression lentivirus in BGC-823 cells. (e) The inhibition of cell proliferation in BGC-823 cells after overexpression of KLF4. (f) Real-time PCR and western blot analyses of KLF4 expression levels after transfection of KLF4 RNAi in BGC-823 cells. (g) The inhibition of cell proliferation in BGC-823 cells after downregulation of KLF4.

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