Study on Antipyretic Properties of Phenolics in Lonicerae Japonicae Flos Based on Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry Combined with Network Pharmacology

Table 1

Binding energy of quantitative components.

No.	Name	Binding energy
		mPGES-1	EP1	EP2	EP3	EP4	Total
P1	Chlorogenic acid	−5.7	−8.0	−8.4	−8.8	−8.2	−39.1
P2	3,5-O-Dicaffeoylquinic acid	−7.0	−9.8	−8.7	−8.2	−10.0	−43.7
P3	4,5-O-Dicaffeoylquinic acid	−6.6	−6.2	−8.9	−8.4	−9.6	−39.7
P4	3,4-Dihydroxybenzoic acid	−4.9	−5.7	−5.8	−5.9	−5.8	−28.1
P5	Methyl caffeate	−5.2	−5.9	−6.2	−6.3	−6.0	−29.6
P6	Chlorogenic acid methyl ester	−5.8	−7.8	−8.6	−8.3	−8.1	−38.6
P7	5-O-Caffeoylquinic acid	−6.2	−8.1	−8.9	−8.8	−8.8	−40.8
P8	4-O-Caffeoylquinic acid	−5.7	−8.0	−8.8	−9.1	−8.3	−39.9
P9	3,4-O-Dicaffeoylquinic acid	−5.4	−7.2	−9.0	−7.9	−9.3	−38.8
P10	Caffeic acid	−5.1	−5.9	−6.4	−6.7	−6.2	−30.3
P11	Ferulic acid	−5.1	−5.7	−6.2	−6.4	−6.1	−29.5
P12	3,5-O-Dicaffeoylquinic acid methyl ester	−6.9	−7.4	−8.0	−8.2	−9.9	−40.4
F1	Quercetin-3-O-rutinoside	−6.4	−8.5	−7.6	−5.3	−8.2	−36.0
F2	Quercetin-3-O-galactoside	−5.6	−7.6	−8.6	−7.3	−8.5	−37.6
F3	Isoquercitrin	−6.1	−6.3	−8.1	−7.7	−8.8	−37.0
F4	Luteolin-7-O-glucoside	−6.4	−9.5	−10.3	−10.4	−9.8	−46.4
F5	Luteolin-7-O-neohesperidoside	−6.6	−7.3	−6.2	−7.7	−7.6	−35.4
F6	Kaempferol-3-O-rutinoside	−6.3	−7.3	−8.1	−5.3	−9.4	−36.4
F7	Kaempferol-3-O-glucoside	−6.0	−8.7	−8.4	−7.2	−8.8	−39.1
F8	Isorhamnetin-3-O-glucoside	−5.7	−6.8	−7.7	−6.7	−8.9	−35.8
F9	Apigenin-7-O-glucoside	−6.8	−6.9	−10.0	−10.8	−9.5	−44.0
F10	Tricin-7-O-glucoside	−5.9	−6.6	−9.3	−8.8	−8.4	−39.0
F11	Luteolin	−6.3	−8.3	−9.0	−9.0	−8.6	−41.2
F12	Quercetin	−6.0	−8.2	−9.0	−8.6	−8.3	−40.1
F13	Diosmetin	−5.8	−8.0	−9.0	−8.5	−8.1	−39.4
F14	Apigenin	−6.4	−8.2	−8.5	−9.4	−8.5	−41.0
F15	Tricin	−5.8	−6.7	−9.3	−8.6	−7.4	−37.8