Allicin-Mediated Cell Cycle Regulation Reverses Taxol Resistance in NSCLC: Molecular Insights and Therapeutic Potentia

Figure 6

Allicin combined with Taxol inhibits tumor growth in an orthotopic A549/Taxol nude mice model by tail vein. (a) The schematic figure of tumor modeling nude mice and drug administration. (b) The images of orthotopic A549/Taxol lung samples in nude mice based on the Bouin’s staining (n = 3). (c) Statistical analysis of the number of lung nodules in mice in each group (n = 3). (d) Body weight change curve of nude mice after drug administrations. (e) Hematoxylin and eosin (HE) staining of lung tissues in each group (400×). (f) The expressions of cyclin B1, CDK1, and p21 in lung tissues were detected by immunohistochemistry. Scale bar = 100 µm. The data were expressed as mean ± SD, compared with the blank control group,  < 0.05,  < 0.01,  < 0.001; ^#compared with the Taxol group,  < 0.05, ^## < 0.01, ^### < 0.001.

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