Morroniside Delays NAFLD Progression in Fructose-Fed Mice by Normalizing Lipid Metabolism and Inhibiting the Inflammatory Response

Figure 4

Morroniside mitigates oxidative stress and inflammatory response in the liver. The ROS intensity (a), content of MDA (b), and T-SOD activity (c) in the liver of the con or fructose-fed mice with intragastric administration of either vehicle or morroniside, respectively (n = 8). (d-f) The contents of inflammatory factors TNF-α, IL-6, and IL-1β in the liver of the con or fructose-fed mice with intragastric administration of either vehicle or morroniside, respectively (n = 8). (g, h) Representative immunoblots and quantification of NLRP3, caspase-1 and IL-1β in liver (n = 3). Mean ± S.D., ^### vs. the con group; , , vs. the fructose-fed group. Con: control.

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