Interaction and Binding Kinetics of Different Substituted Pyrazines with HSA: Based on Multispectral, Physiological Activity, and Molecular Dynamics Simulations

Table 4

Conformational changes of HSA with different substituent pyrazine compounds.

	α-Helix (%)	β-Sheet (%)	β-Turn (%)	Random coil (%)
2,3-DMTP	61.7	7.5	12.9	17.6
	60.4	7.9	13	18.2
	58.9	8.2	13.2	18.8
	57.2	8.6	13.4	19.6
2,5-DMTP	61.7	7.5	12.9	17.6
	59.9	7.9	13.1	18.4
	57.7	8.5	13.4	19.4
	56	8.9	13.6	20.2
TMTP	61.7	7.5	12.9	17.6
	60.3	7.9	13.1	18.2
	59.1	8.1	13.2	18.8
	58.9	8.2	13.2	18.9
TTMP	62.4	7.4	12.8	17.3
	61.6	7.6	12.9	17.6
	60.1	7.9	13.1	18.3
	58.1	8.4	13.3	19.2